Journal article
Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study
Alzheimer's & dementia, Vol.22(7), e71627
2026
PMID: 42410716
Abstract
Introduction
Poor sleep is associated with neurodegenerative disease, but mechanisms are unclear. Greater volume of the choroid plexus (ChP), a brain structure supporting neurotoxic waste clearance, is linked to neurodegeneration and cognitive decline. We tested whether poor sleep promotes neurodegeneration and cognitive deficits via ChP dysfunction.
Methods
Baseline magnetic resonance imaging (MRI) -derived ChP, hippocampal, ventricular, and gray matter volumes from 635 cognitively unimpaired older adults were analyzed. Sleep was measured with the Pittsburgh Sleep Quality Index and accelerometry. Confirmatory factor analysis generated cognitive domain scores.
Results
Poorer self-reported sleep quality was associated with greater ChP volume, while accelerometry measures were not. Greater ChP volume was associated with smaller hippocampi and gray matter, and larger ventricles. ChP mediated relationships between sleep quality and hippocampal and ventricular volumes. Gray matter mediated associations between ChP and cognitive domains.
Discussion
Altered ChP morphology may link poor sleep to neurodegeneration and cognitive decline in older adults.
Details
- Title
- Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study
- Authors/Creators
- Miranda G Chappel-Farley - University of PittsburghKelsey R Sewell - Murdoch UniversityAudrey M Collins - Translational Research Institute for Metabolism and DiabetesCristina Molina-Hidalgo - AdventHealth OrlandoShivangi Jain - Translational Research Institute for Metabolism and DiabetesHaiqing Huang - Translational Research Institute for Metabolism and DiabetesPatricio Solis-Urra - Translational Research Institute for Metabolism and DiabetesLauren E Oberlin - Cornell UniversityGeorge Grove - University of PittsburghArthur F Kramer - University of Illinois Urbana-ChampaignEdward McAuley - University of Illinois Urbana-ChampaignJeffrey M Burns - University of Illinois Urbana-ChampaignCharles Hillman - Northeastern UniversityEric D Vidoni - Northeastern UniversityBradley P Sutton - University of Illinois Urbana-ChampaignAnna L Marsland - University of PittsburghM Ilyas Kamboh - University of PittsburghChaeryon Kang - University of PittsburghLu Wan - Translational Research Institute for Metabolism and DiabetesKirk I Erickson - AdventHealth OrlandoKristine A Wilckens - University of Pittsburgh
- Publication Details
- Alzheimer's & dementia, Vol.22(7), e71627
- Publisher
- Wiley Periodicals LLC on behalf of Alzheimer’s Association
- Number of pages
- 14
- Grant note
- R01 AG053952 / NIA NIH HHS T32HL082610 / NHLBI NIH HHS R35 AG072307 / NIA NIH HHS
- Identifiers
- 991005902203707891
- Copyright
- © 2026 The Author(s).
- Murdoch Affiliation
- School of Psychology
- Language
- English
- Resource Type
- Journal article
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