Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review

Mohamed T El-Saadony; Guihong Fang; Si Yan; Samar Sami Alkafaas; Mahmoud A El Nasharty; Sohila A Khedr; Aya Misbah Hussien; Soumya Ghosh; Mthokozisi Dladla; Sara Samy Elkafas; Essam H Ibrahim; Heba Mohammed Salem; Walid F A Mosa; Ahmed Ezzat Ahmed; Dina Mostafa Mohammed; Sameh A Korma; Marawan K El-Tarabily; Ahmed M Saad; Khaled A El-Tarabily; Synan F AbuQamar

doi:10.2147/IJN.S487188

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Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review

Journal article

Open access

Peer reviewed

Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review

Mohamed T El-Saadony, Guihong Fang, Si Yan, Samar Sami Alkafaas, Mahmoud A El Nasharty, Sohila A Khedr, Aya Misbah Hussien, Soumya Ghosh, Mthokozisi Dladla, Sara Samy Elkafas, …

International journal of nanomedicine, Vol.19, pp.12889-12937

2024

DOI: https://doi.org/10.2147/IJN.S487188

PMID: 39651353

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Abstract

Animals

Anti-Bacterial Agents - chemistry

Anti-Bacterial Agents - pharmacology

Antineoplastic Agents - chemistry

Antineoplastic Agents - pharmacology

Biosensing Techniques - methods

Green Chemistry Technology - methods

Humans

Metal Nanoparticles - chemistry

Reactive Oxygen Species - metabolism

Zinc Oxide - chemistry

Zinc Oxide - pharmacology

Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for their wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, and drug/gene delivery. Among these, zinc oxide (ZnO) NPs stand out for their versatility and effectiveness. Recently, ZnO NPs have become a primary material in various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, and automotive industries. ZnO NPs can generate reactive oxygen species and induce cellular apoptosis, thus underpinning their potent anticancer and antibacterial properties. To meet the growing demand, numerous synthetic approaches have been developed to produce ZnO NPs. However, traditional manufacturing processes often involve significant economic and environmental costs, prompting a search for more sustainable alternatives. Intriguingly, biological synthesis methods utilizing plants, plant extracts, or microorganisms have emerged as ideal for producing ZnO NPs. These green production techniques offer numerous medicinal, economic, environmental, and health benefits. This review highlights the latest advancements in the green synthesis of ZnO NPs and their biomedical applications, showcasing their potential to revolutionize the field with eco-friendly and cost-effective solutions.

Details

Title: Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review
Authors/Creators: Mohamed T El-Saadony - Zagazig University
Guihong Fang - Hainan Medical University
Si Yan - Qionghai People's Hospital, Qionghai, Hainan, 571400, People's Republic of China
Samar Sami Alkafaas - Tanta University
Mahmoud A El Nasharty - Ain Shams University
Sohila A Khedr - Tanta University
Aya Misbah Hussien - Alexandria University
Soumya Ghosh - University of Nizwa
Mthokozisi Dladla - University of the Free State
Sara Samy Elkafas - Menoufia University
Essam H Ibrahim - King Khalid University
Heba Mohammed Salem - Cairo University
Walid F A Mosa - Alexandria University
Ahmed Ezzat Ahmed - King Khalid University
Dina Mostafa Mohammed - National Research Centre
Sameh A Korma - Zagazig University
Marawan K El-Tarabily - University of Debrecen
Ahmed M Saad - Zagazig University
Khaled A El-Tarabily - United Arab Emirates University
Synan F AbuQamar - United Arab Emirates University
Publication Details: International journal of nanomedicine, Vol.19, pp.12889-12937
Publisher: Dove Press
Number of pages: 49
Grant note: Finance Science and Technology Project of Hainan Province: ZDYF2019031 UAEU program of Advanced Research: 21S169 Khalifa Center for Biotechnology and Genetic Engineering-UAEU: 31R286
This work was financially supported by the Finance Science and Technology Project of Hainan Province (ZDYF2019031); UAEU program of Advanced Research (Grant number: 21S169) and Khalifa Center for Biotechnology and Genetic Engineering-UAEU (Grant #: 31R286).
Identifiers: 991005724214307891
Murdoch Affiliation: Centre for Terrestrial Ecosystem Science and Sustainability
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.67 Nanoparticles; 2.67.231 Nanotoxicology
Web Of Science research areas: Nanoscience & Nanotechnology; Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology