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Journal article
Gut-Spleen Axis: Microbiota via vascular and immune pathways improve Busulfan-Induced spleen disruption
mSphere, Vol.8(1), e0058122
2023
PMID: 36511706
Abstract
Fecal microbiota transplantation (FMT) is an effective means of modulating gut microbiota for the treatment of many diseases, including Clostridioides diffictle infections. The gut-spleen axis has been established, and this is involved in the development and function of the spleen. However, it is not understood whether gut microbiota can be used to improve spleen function, especially in spleens disrupted by a disease or an anti-cancer treatment. In the current investigation, we established that alginate oligosaccharide (AOS)-improved gut microbiota (A10-FMT) can rescue anticancer drug busulfan-disrupted spleen vasculature and spleen function. A10-FMT improved the gene and/or protein expression of genes involved in vasculature development, increased the cell proliferation rate, enhanced the endothelial progenitor cell capability, and elevated the expression of the cell junction molecules to increase the vascularization of the spleen. This investigation found for the first time that the reestablishment of spleen vascularization restored spleen function by improving spleen immune cells and iron metabolism. These findings may be used as a strategy to minimize the side effects of anti-cancer drugs or to improve spleen vasculaturerelated diseases.
IMPORTANCE Alginate oligosaccharide (AOS)-improved gut microbiota (A10-FMT) can rescue busulfan disrupted spleen vasculature. A10-FMT improved the cell proliferation rate, endothelial progenitor cell capability, and cell junction molecules to increase vasculature formation in the spleen. This reestablishment restored spleen function by improving spleen immune cells and iron metabolism. These findings are useful for the treatment of spleen vasculature-related diseases.
Details
- Title
- Gut-Spleen Axis: Microbiota via vascular and immune pathways improve Busulfan-Induced spleen disruption
- Authors/Creators
- Hanhan Fang - Qingdao Agr Univ, Coll Life Sci, Qingdao, Peoples R ChinaXiaohui Feng - Institute of Animal SciencesTao Xu - Qingdao Agr Univ, Coll Life Sci, Qingdao, Peoples R ChinaRuqing Zhong - Institute of Animal SciencesDongxin Lu - Qingdao Agr Univ, Coll Life Sci, Qingdao, Peoples R ChinaHongfu Zhang - Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R ChinaWei Shen - Qingdao Agr Univ, Coll Life Sci, Qingdao, Peoples R ChinaYong Zhao - Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R ChinaLiang Chen - Institute of Animal SciencesJunjie Wang - Qingdao Agricultural University
- Publication Details
- mSphere, Vol.8(1), e0058122
- Publisher
- American Society for Microbiology
- Number of pages
- 13
- Grant note
- 31772408; 31672428 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2021LZGC001 / Key Research and Development Program of Shandong Province ts20190946 / Taishan Scholar Foundation of Shandong Province of China
- Identifiers
- 991005585961107891
- Copyright
- © 2022 Fang et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.384 Gut Microbiota
- Web Of Science research areas
- Microbiology
- ESI research areas
- Microbiology