Journal article
Gut microbiota composition in relation to intake of added sugar, sugar-sweetened beverages and artificially sweetened beverages in the Malmö Offspring Study
European Journal of Nutrition, Vol.60, pp.2087-2097
2020
Abstract
Purpose
It has been suggested that a high intake of sugar or sweeteners may result in an unfavorable microbiota composition; however, evidence is lacking. Hence, in this exploratory epidemiological study, we aim to examine if intake of added sugar, sugar-sweetened beverages (SSBs) or artificially sweetened beverages (ASBs) associate with the gut microbiota composition.
Methods
Participants (18–70 years) in the Malmö Offspring Study have provided blood, urine, and fecal samples and completed both web-based 4 day food records and short food frequency questionnaires. The gut microbiota was assessed by 16S rRNA sequencing, processed in QIIME and matched to Greengenes (v.13.8), giving 64 included genera after filtering. Intake of added sugar (n = 1371) (also supported by the overnight urinary sugar biomarker in a subgroup n = 577), SSBs (n = 1086) and ASBs (n = 1085) were examined as exposures in negative binomial regressions.
Results
Various genera nominally associated with intake of added sugar, SSBs, and ASBs. Only the negative association between SSB intake and Lachnobacterium remained significant after multiple testing correction. A positive association between SSB intake and the Firmicutes:Bacteroidetes ratio was also observed.
Conclusion
In this wide population, the cross-sectional associations between added sugar and sweet beverage intake and the gut microbiota are modest, but the results suggest that SSB intake is associated negatively with the genus Lachnobacterium and positively with the Firmicutes:Bacteroidetes ratio. Larger studies, preferably using metagenomic sequencing, are needed to further evaluate if a link exists between intake of sugars and sweeteners and the human gut microbiota.
Details
- Title
- Gut microbiota composition in relation to intake of added sugar, sugar-sweetened beverages and artificially sweetened beverages in the Malmö Offspring Study
- Authors/Creators
- S. Ramne (Author/Creator) - Malmö UniversityL. Brunkwall (Author/Creator) - Malmö UniversityU. Ericson (Author/Creator) - Malmö UniversityN. Gray (Author/Creator) - Murdoch UniversityG.G.C. Kuhnle (Author/Creator) - University of ReadingP.M. Nilsson (Author/Creator) - Malmö UniversityM. Orho-Melander (Author/Creator) - Malmö UniversityE. Sonestedt (Author/Creator) - Malmö University
- Publication Details
- European Journal of Nutrition, Vol.60, pp.2087-2097
- Publisher
- Springer Nature
- Identifiers
- 991005541420307891
- Copyright
- © 2020 Springer Nature Switzerland AG.
- Murdoch Affiliation
- Australian National Phenome Centre
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.384 Gut Microbiota
- Web Of Science research areas
- Nutrition & Dietetics
- ESI research areas
- Clinical Medicine