Journal article
Gut-muscle crosstalk. A perspective on influence of microbes on muscle function
Frontiers in medicine, Vol.9, 1065365
2023
PMID: 36698827
Abstract
Our gastrointestinal system functions to digest and absorb ingested food, but it is also home to trillions of microbes that change across time, nutrition, lifestyle, and disease conditions. Largely commensals, these microbes are gaining prominence with regards to how they collectively affect the function of important metabolic organs, from the adipose tissues to the endocrine pancreas to the skeletal muscle. Muscle, as the biggest utilizer of ingested glucose and an important reservoir of body proteins, is intricately linked with homeostasis, and with important anabolic and catabolic functions, respectively. Herein, we provide a brief overview of how gut microbiota may influence muscle health and how various microbes may in turn be altered during certain muscle disease states. Specifically, we discuss recent experimental and clinical evidence in support for a role of gut-muscle crosstalk and include suggested underpinning molecular mechanisms that facilitate this crosstalk in health and diseased conditions. We end with a brief perspective on how exercise and pharmacological interventions may interface with the gut-muscle axis to improve muscle mass and function.
Details
- Title
- Gut-muscle crosstalk. A perspective on influence of microbes on muscle function
- Authors/Creators
- Weixuan Chew - Nanyang Technological UniversityYen Peng Lim - Tan Tock Seng HospitalWee Shiong Lim - Nanyang Technological UniversityEdward S. Chambers - Imperial College LondonGary Frost - Imperial College LondonSunny Hei Wong - Nanyang Technological UniversityYusuf Ali - Nanyang Technological University
- Publication Details
- Frontiers in medicine, Vol.9, 1065365
- Publisher
- Frontiers Media Sa
- Number of pages
- 14
- Grant note
- MOE2018-T2-1-085; MOE-T2EP30221-0003; 2019-T1-001-059 / Ministry of Education Singapore; Ministry of Education, Singapore Wang Lee Wah Memorial Fund 021337-00001 / LKC Medicine Healthcare Research Fund (Diabetes Research)
- Identifiers
- 991005884850007891
- Copyright
- © 2023 Chew, Lim, Lim, Chambers, Frost, Wong and Ali.
- Murdoch Affiliation
- Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
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