Journal article
HFE C282Y homozygotes are at increased risk of breast and colorectal cancer
Hepatology, Vol.51(4), pp.1311-1318
2009
Abstract
The evidence that mutations in the HFE gene for hemochromatosis are associated with increased cancer risk is inconsistent. The Melbourne Collaborative Cohort Study is a prospective cohort study that commenced recruitment in 1990. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 28,509) were genotyped for the HFE C282Y (substitution of tyrosine for cysteine at amino acid 282) variant. Incident cancers were ascertained from Australian cancer registries during an average of 14 years follow-up. Hazard ratios (HRs), confidence intervals (CIs), and P values were obtained from separate Cox regression analyses for colorectal, breast, and prostate cancers, all other solid cancers, and all cancers. Compared to those with no C282Y variant, C282Y homozygotes were at increased risk of colorectal cancer (HR = 2.28; 95% CI = 1.22, 4.25; P = 0.01) and female C282Y homozygotes were at increased risk of developing breast cancer (HR = 2.39; 95% CI = 1.24, 4.61; P = 0.01), but male C282Y homozygotes were not at increased risk for prostate cancer (HR = 0.96; 95% CI = 0.43, 2.15; P = 0.92). C282Y/H63D compound heterozygotes were not at increased risk for colorectal cancer (HR = 1.27; 95% CI = 0.80, 2.01), breast cancer (HR = 1.16; 95% CI = 0.74, 1.84), or prostate cancer (HR = 1.08; 95% CI = 0.68, 1.70). Conclusion: HFE C282Y homozygotes have twice the risk of colorectal and breast cancer compared with those individuals without the C282Y variant.
Details
- Title
- HFE C282Y homozygotes are at increased risk of breast and colorectal cancer
- Authors/Creators
- N.J. Osborne (Author/Creator) - Murdoch Children's Research InstituteL.C. Gurrin (Author/Creator) - The University of MelbourneK.J. Allen (Author/Creator) - Royal Children's HospitalC.C. Constantine (Author/Creator) - The University of MelbourneM.B. Delatycki (Author/Creator) - The University of MelbourneC.E. McLaren (Author/Creator) - University of California, IrvineD.M. Gertig (Author/Creator) - The University of MelbourneG.J. Anderson (Author/Creator) - QIMR Berghofer Medical Research InstituteM.C. Southey (Author/Creator) - The University of MelbourneJ.K. Olynyk (Author/Creator) - Fremantle HospitalL.W. Powell (Author/Creator) - QIMR Berghofer Medical Research InstituteJ.L. Hopper (Author/Creator) - The University of MelbourneG.G. Giles (Author/Creator) - Cancer Council VictoriaD.R. English (Author/Creator) - Cancer Council Victoria
- Publication Details
- Hepatology, Vol.51(4), pp.1311-1318
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005541035507891
- Copyright
- © 2009 American Association for the Study of Liver Diseases
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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