Journal article
HIV/AIDS: HIV: Experiencing the pressures of modern life
Science, Vol.307(5714), pp.1422-1424
2005
Abstract
HIV/AIDS HIV, the wily virus that causes AIDS, is able to outwit any number of host immune defenses that it encounters during infection. However, as Nolan, James and Mallal discuss in their Perspective, there is increasing evidence that small pockets of individuals are relatively protected against HIV infection, and also experience less aggressive HIV disease progression, due to a fortuitous genetic barrier. The Perspective authors discuss the finding that a low copy number of the gene encoding CCL3L1, a ligand for CCR5 (the coreceptor that HIV must bind to for invasion of human T cells to proceed), can markedly alter HIV disease outcomes. The authors discuss the need to take into account genetic barriers like the CCR5-CCL3L1 network when developing vaccines against HIV.
Details
- Title
- HIV/AIDS: HIV: Experiencing the pressures of modern life
- Authors/Creators
- D. Nolan (Author/Creator) - Royal Perth HospitalI. James (Author/Creator) - Royal Perth HospitalS. Mallal (Author/Creator) - Royal Perth Hospital
- Publication Details
- Science, Vol.307(5714), pp.1422-1424
- Publisher
- American Association for the Advancement of Science
- Identifiers
- 991005546001707891
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Multidisciplinary Sciences
- ESI research areas
- Multidisciplinary