HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

T. Miura; C. J. Brumme; M. A. Brockman; Z. L. Brumme; F. Pereyra; B. L. Block; A. Trocha; M. John; S. Mallal; P. R. Harrigan; B. D. Walker

doi:10.1128/JVI.02459-08

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HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

Journal article

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Peer reviewed

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

T. Miura, C. J. Brumme, M. A. Brockman, Z. L. Brumme, F. Pereyra, B. L. Block, A. Trocha, M. John, S. Mallal, P. R. Harrigan, …

Journal of Virology, Vol.83(7), pp.3407-3412

2009

DOI: https://doi.org/10.1128/JVI.02459-08

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Abstract

Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8⁺ T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC., compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HTV-1 infection.

Details

Title: HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers
Authors/Creators: T. Miura (Author/Creator) - Howard Hughes Medical Institute
C. J. Brumme (Author/Creator) - Ragon Institute of MGH, MIT and Harvard
M. A. Brockman (Author/Creator) - Ragon Institute of MGH, MIT and Harvard
Z. L. Brumme (Author/Creator) - Ragon Institute of MGH, MIT and Harvard
F. Pereyra (Author/Creator) - Ragon Institute of MGH, MIT and Harvard
B. L. Block (Author/Creator) - Harvard University
A. Trocha (Author/Creator) - Howard Hughes Medical Institute
M. John (Author/Creator) - Royal Perth Hospital
S. Mallal (Author/Creator) - Royal Perth Hospital
P. R. Harrigan (Author/Creator) - University of British Columbia
B. D. Walker (Author/Creator) - Howard Hughes Medical Institute
Publication Details: Journal of Virology, Vol.83(7), pp.3407-3412
Publisher: American Society for Microbiology
Identifiers: 991005546031707891
Copyright: © 2009, American Society for Microbiology
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Virology
ESI research areas: Microbiology