Journal article
HLA-DR allele polymorphism and multiple sclerosis in Chinese populations: a meta-analysis
Multiple Sclerosis, Vol.17(4), pp.382-388
2011
Abstract
Background: The association of human leukocyte antigen (HLA) genes and multiple sclerosis (MS) has been extensively investigated in Caucasians, but less so in Oriental races such as Chinese. Objectives: To review studies on association of HLA class II alleles with MS in the Chinese population. Methods: An extensive search for published studies up to June 2010 was performed in the electronic databases. The meta-analysis facilities in the NCSS statistical package were utilized to analyze the findings in these studies. The odds ratios (ORs) of HLA-DR allele distributions in MS were analyzed against controls. Results: Eleven case-control studies were identified: nine genotyping and two serotyping studies. Six genotyping studies were suitable for HLA-DRB1 allele meta-analysis, which showed that HLA-DRB1*15 was associated with risk of MS in the combined group (308 cases and 407 controls; OR 1.39) while the HLA-DRB1*09 and HLA-DRB1*0901 alleles were protective. When the equivalent serotypes in these six studies were combined with the results from the two serotyping studies (431 cases and 652 controls) for a meta-analysis of HLA-DR serotypes, HLA-DR2 was a risk factor (OR 1.63) and HLA-DR9 was strongly protective in the combined group (OR 0.64). Conclusions: Although limited data are available, our meta-analysis suggests that HLA-DR2/DRB1*15 are also associated with risk of MS in the Chinese population but less strongly so than in Western MS populations, whereas HLA-DR9 alleles appear to confer resistance in this population.
Details
- Title
- HLA-DR allele polymorphism and multiple sclerosis in Chinese populations: a meta-analysis
- Authors/Creators
- W. Qiu (Author/Creator)I. James (Author/Creator)W.M. Carroll (Author/Creator)F.L. Mastaglia (Author/Creator)A.G. Kermode (Author/Creator)
- Publication Details
- Multiple Sclerosis, Vol.17(4), pp.382-388
- Publisher
- SAGE Publications
- Identifiers
- 991005540561007891
- Copyright
- © The Author(s) 2010.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior