HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand

C. Kongmaroeng; A. Romphruk; C. Puapairoj; C. Leelayuwat; J.K. Kulski; H. Inoko; D.S. Dunn; A.V. Romphruk

doi:10.1111/tan.12637

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HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand

Journal article

Peer reviewed

HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand

C. Kongmaroeng, A. Romphruk, C. Puapairoj, C. Leelayuwat, J.K. Kulski, H. Inoko, D.S. Dunn and A.V. Romphruk

Tissue Antigens, Vol.86(3), pp.199-204

2015

DOI: https://doi.org/10.1111/tan.12637

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Abstract

This is the first report on human leukocyte antigen (HLA) allele and haplotype frequencies at three class I loci and two class II loci in unrelated healthy individuals from two ethnic groups, 170 Burmese and 200 Karen, originally from Burma (Myanmar), but sampled while residing in Thailand. Overall, the HLA allele and haplotype frequencies detected by polymerase chain reaction sequence-specific primer (PCR-SSP) at five loci (A, B, C, DRB1 and DRQB1) at low resolution showed distinct differences between the Burmese and Karen. In Burmese, five HLA-B*15 haplotypes with different HLA-A and HLA-DR/DQ combinations were detected with three of these not previously reported in other Asian populations. The data are important in the fields of anthropology, transplantation and disease-association studies.

Details

Title: HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand
Authors/Creators: C. Kongmaroeng (Author/Creator)
A. Romphruk (Author/Creator)
C. Puapairoj (Author/Creator)
C. Leelayuwat (Author/Creator)
J.K. Kulski (Author/Creator)
H. Inoko (Author/Creator)
D.S. Dunn (Author/Creator)
A.V. Romphruk (Author/Creator)
Publication Details: Tissue Antigens, Vol.86(3), pp.199-204
Publisher: Blackwell Publishing
Identifiers: 991005543370607891
Copyright: © 2015 John Wiley & Sons A/S.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Cell Biology; Immunology; Pathology
ESI research areas: Molecular Biology & Genetics