Journal article
HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy
Proceedings of the National Academy of Sciences, Vol.96(7), pp.3848-3853
1999
Abstract
The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load. However, it is not known whether a persistent class I HLA-restricted antiviral cytotoxic T lymphocyte (CTL) response reduces viral load and is therefore beneficial or causes tissue damage and contributes to disease pathogenesis. HTLV-I-associated myelopathy (HAM/TSP) patients have a high virus load compared with asymptomatic HTLV-I carriers. We hypothesized that HLA alleles control HTLV-I provirus load and thus influence susceptibility to HAM/TSP. Here we show that, after infection with HTLV-I, the class I allele HLA-A*02 halves the odds of HAM/TSP (P < 0.0001), preventing 28% of potential cases of HAM/TSP. Furthermore, HLA-A*02+ healthy HTLV-I carriers have a proviral load one-third that (P = 0.014) of HLA-A*02− HTLV-I carriers. An association of HLA-DRB1*0101 with disease susceptibility also was identified, which doubled the odds of HAM/TSP in the absence of the protective effect of HLA-A*02. These data have implications for other persistent virus infections in which virus load is associated with prognosis and imply that an efficient antiviral CTL response can reduce virus load and so prevent disease in persistent virus infections.
Details
- Title
- HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy
- Authors/Creators
- K.J.M. Jeffery (Author/Creator)K. Usuku (Author/Creator)S.E. Hall (Author/Creator)W. Matsumoto (Author/Creator)G.P. Taylor (Author/Creator)J. Procter (Author/Creator)M. Bunce (Author/Creator)G.S. Ogg (Author/Creator)K.I. Welsh (Author/Creator)J.N. Weber (Author/Creator)A.L. Lloyd (Author/Creator)M.A. Nowak (Author/Creator)M. Nagai (Author/Creator)D. Kodama (Author/Creator)S. Izumo (Author/Creator)M. Osame (Author/Creator)C.R.M. Bangham (Author/Creator)
- Publication Details
- Proceedings of the National Academy of Sciences, Vol.96(7), pp.3848-3853
- Publisher
- National Academy of Sciences
- Identifiers
- 991005544795007891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.1464 HTLV-1/BLV Pathogenesis
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology