HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia

K. Maitland; M. Bunce; R.M. Harding; M.C.N.M. Barnardo; J.B. Clegg; K. Welsh; D.K. Bowden; T.N. Williams

doi:10.1111/j.1399-0039.2004.00328.x

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HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia

Journal article

Peer reviewed

HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia

K. Maitland, M. Bunce, R.M. Harding, M.C.N.M. Barnardo, J.B. Clegg, K. Welsh, D.K. Bowden and T.N. Williams

Tissue Antigens, Vol.64(6), pp.678-686

2004

DOI: https://doi.org/10.1111/j.1399-0039.2004.00328.x

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Abstract

HLA class-I and class-II allele frequencies and two-locus haplotypes were examined in 367 unrelated Melanesians living on the islands of Vanuatu and New Caledonia. Diversity at all HLA class-I and class-II loci was relatively limited. In class-I loci, three HLA-A allelic groups (HLA-A*24, HLA-A*34 and HLA-A*11), seven HLA-B alleles or allelic groups (HLA-B*1506, HLA-B*5602, HLA-B*13, HLA-B*5601, HLA-B*4001, HLA-B*4002 and HLA-B*2704) and four HLA-C alleles or allelic groups (HLA-Cw*04, HLA-Cw*01, HLA-Cw*0702 and HLA-Cw*15) constituted more than 90% of the alleles observed. In the class-II loci, four HLA-DRB1 alleles (HLA-DRB1*15, HLA-DRB1*11, HLA-DRB1*04 and HLA-DRB1*16), three HLA-DRB3-5 alleles (HLA-DRB3*02, HLA-DRB4*01 and HLA-DRB5*01/02) and five HLA-DQB1 alleles (HLA-DQB1*0301, HLA-DQB1*04, HLA-DQB1*05, HLA-DQB1*0601 and HLA-DQB1*0602) constituted over 93, 97 and 98% of the alleles observed, respectively. Homozygosity showed significant departures from expected levels for neutrality based on allele frequency (i.e. excess diversity) at the HLA-B, HLA-Cw, HLA-DQB1 and HLA-DRB3/5 loci on some islands. The locus with the strongest departure from neutrality was HLA-DQB1, homozygosity being significantly lower than expected on all islands except New Caledonia. No consistent pattern was demonstrated for any HLA locus in relation to malaria endemicity.

Details

Title: HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia
Authors/Creators: K. Maitland (Author/Creator) - St Mary's Hospital
M. Bunce (Author/Creator) - Churchill Hospital
R.M. Harding (Author/Creator) - Massachusetts Rehabilitation Commission
M.C.N.M. Barnardo (Author/Creator)
J.B. Clegg (Author/Creator) - Massachusetts Rehabilitation Commission
K. Welsh (Author/Creator) - Churchill Hospital
D.K. Bowden (Author/Creator) - Monash University
T.N. Williams (Author/Creator) - Massachusetts Rehabilitation Commission
Publication Details: Tissue Antigens, Vol.64(6), pp.678-686
Publisher: Blackwell Publishing
Identifiers: 991005542354207891
Copyright: © 2004 Blackwell Munksgaard
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Cell Biology; Immunology; Pathology
ESI research areas: Molecular Biology & Genetics