HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

A. Rauch; D. Nolan; H. Furrer; E. McKinnon; M. John; S. Mallal; S. Gaudieri; H.F. Günthard; P. Schmid; M. Battegay; B. Hirschel; A. Telenti; I. James; . Swiss HIV Cohort Study

doi:10.1086/588479

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HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

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HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

A. Rauch, D. Nolan, H. Furrer, E. McKinnon, M. John, S. Mallal, S. Gaudieri, H.F. Günthard, P. Schmid, M. Battegay, …

Clinical Infectious Diseases, Vol.46(12), pp.1921-1925

2008

DOI: https://doi.org/10.1086/588479

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Abstract

We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/μL for HLA-Bw4 homozygotes, 321 cells/μL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/μL for HLA-Bw6 homozygotes (P = .01 , compared with HLA- Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.

Details

Title: HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy
Authors/Creators: A. Rauch (Author/Creator)
D. Nolan (Author/Creator)
H. Furrer (Author/Creator)
E. McKinnon (Author/Creator)
M. John (Author/Creator)
S. Mallal (Author/Creator)
S. Gaudieri (Author/Creator)
H.F. Günthard (Author/Creator)
P. Schmid (Author/Creator)
M. Battegay (Author/Creator)
B. Hirschel (Author/Creator)
A. Telenti (Author/Creator)
I. James (Author/Creator)
. Swiss HIV Cohort Study (Author/Creator)
Publication Details: Clinical Infectious Diseases, Vol.46(12), pp.1921-1925
Publisher: University of Chicago Press
Identifiers: 991005540418307891
Copyright: © 2008 by the Infectious Diseases Society of America
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology
ESI research areas: Immunology