Journal article
Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease
Alzheimer's & Dementia, Vol.13(11), pp.1197-1206
2017
Abstract
Introduction: The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers.
Methods: In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42, and CSF tau levels was evaluated using linear regression.
Results: No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels.
Discussion: Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.
Details
- Title
- Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease
- Authors/Creators
- B.M. Brown (Author/Creator) - Edith Cowan UniversityH.R. Sohrabi (Author/Creator) - Edith Cowan UniversityK. Taddei (Author/Creator) - Edith Cowan UniversityS.L. Gardener (Author/Creator) - Edith Cowan UniversityS.R. Rainey-Smith (Author/Creator)J.J. Peiffer (Author/Creator) - Murdoch UniversityC. Xiong (Author/Creator) - Washington University in St. LouisA.M. Fagan (Author/Creator) - Washington University in St. LouisT. Benzinger (Author/Creator)V. Buckles (Author/Creator) - Washington University in St. LouisK.I. Erickson (Author/Creator) - University of PittsburghR. Clarnette (Author/Creator) - The University of Western AustraliaT. Shah (Author/Creator) - Australian Alzheimer’s Research FoundationC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthM. Weiner (Author/Creator) - San Francisco VA Medical CenterN. Cairns (Author/Creator) - Washington University in St. LouisM. Rossor (Author/Creator) - UK Dementia Research InstituteN.R. Graff-Radford (Author/Creator) - Jacksonville CollegeS. Salloway (Author/Creator) - Brown UniversityJ. Vöglein (Author/Creator) - Ludwig-Maximilians-Universität MünchenC. Laske (Author/Creator) - German Center for Neurodegenerative DiseasesJ. Noble (Author/Creator) - Columbia University Irving Medical CenterP.R. Schofield (Author/Creator) - Neuroscience Research AustraliaR.J. Bateman (Author/Creator) - Washington University in St. LouisJ.C. Morris (Author/Creator) - Washington University in St. LouisR.N. Martins (Author/Creator) - Edith Cowan University
- Publication Details
- Alzheimer's & Dementia, Vol.13(11), pp.1197-1206
- Publisher
- Elsevier Inc.
- Identifiers
- 991005541316207891
- Copyright
- © 2017 The Alzheimer's Association
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior