Hand eczema and changes in the skin microbiome after 2 weeks of topical corticosteroid treatment

Line Brok Nørreslet; Anna Cäcilia Ingham; Tove Agner; Caroline Meyer Olesen; Anne Bregnhøj; Mette Sommerlund; Paal Skytt Andersen; Marc Stegger; Charlotte Gotthard Mørtz; Sofie Marie Edslev

doi:10.1111/jdv.20366

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Hand eczema and changes in the skin microbiome after 2 weeks of topical corticosteroid treatment

Journal article

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Hand eczema and changes in the skin microbiome after 2 weeks of topical corticosteroid treatment

Line Brok Nørreslet, Anna Cäcilia Ingham, Tove Agner, Caroline Meyer Olesen, Anne Bregnhøj, Mette Sommerlund, Paal Skytt Andersen, Marc Stegger, Charlotte Gotthard Mørtz and Sofie Marie Edslev

Journal of the European Academy of Dermatology and Venereology, Vol.39(6), pp.1118-1125

2024

DOI: https://doi.org/10.1111/jdv.20366

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Abstract

Background More than 50% of patients with hand eczema (HE) are colonized with Staphylococcus aureus. Comprehensive knowledge of the skin microbiome and its changes in patients with HE may provide insights into future potential therapeutical targets. Objective To describe the skin microbiome in patients with moderate-to-severe chronic HE and assess its changes following treatment with topical corticosteroids (TCS). Methods Bacterial samples were collected from lesional and nonlesional skin before and after 2 weeks of TCS treatment using ESwabs and analysed by 16S rRNA and tuf gene sequencing. Clinically, the disease severity was assessed by the Hand Eczema Severity Index (HECSI). Results A cohort of 31 patients with HE were included and followed up. Compared to nonlesional skin, lesional skin differed in overall bacterial community composition (p = 0.02), displayed higher relative abundance of Staphylococcus, in particular S. aureus (p = 0.01) and lower abundance of Micrococcus (p = 0.02). As disease severity improved with treatment, these microbial characteristics on lesional skin shifted towards that of nonlesional skin on the hands. Conclusion The bacterial skin microbiome was altered in lesions of HE and partly driven by S. aureus colonization, however, shifted towards nonlesional skin following treatment. Our results emphasize the future possibilities for anti-S. aureus treatment strategies.

Details

Title: Hand eczema and changes in the skin microbiome after 2 weeks of topical corticosteroid treatment
Authors/Creators: Line Brok Nørreslet - Bispebjerg Hospital
Anna Cäcilia Ingham - Statens Serum Institut
Tove Agner - Bispebjerg Hospital
Caroline Meyer Olesen - Bispebjerg Hospital
Anne Bregnhøj - Aarhus University Hospital
Mette Sommerlund - Aarhus University Hospital
Paal Skytt Andersen - Statens Serum Institut
Marc Stegger - Statens Serum Institut
Charlotte Gotthard Mørtz - Odense University Hospital
Sofie Marie Edslev - Statens Serum Institut
Publication Details: Journal of the European Academy of Dermatology and Venereology, Vol.39(6), pp.1118-1125
Publisher: John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.
Number of pages: 8
Grant note: The authors would like to thank the patients who participated in the study and all the departments involved who provided facilities.
Identifiers: 991005707263907891
Copyright: © 2024 The Author(s).
Murdoch Affiliation: Harry Butler Institute
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.265 Dermatology - Skin Allergies; 1.265.939 Contact Dermatitis
Web Of Science research areas: Dermatology
ESI research areas: Clinical Medicine