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Journal article
Harnessing the benefits of utilizing the optimal pH in conjunction with a hydrogel for wound care
Journal of drug delivery science and technology, Vol.89, 105027
2023
Abstract
A hydrogel formulation was developed by combining natural chitosan formulated in the optimal citric acid buffer as a potential approach for managing infected chronic wounds. The combination of chitosan antimicrobial and wound healing properties with citric acid function in mediating cellular processes within the wound healing cascade provided a new strategy to combat infection and promote wound healing. Chitosan-citric acid hydrogel formulated at pH 4 was found to provide strong antimicrobial properties against both Staphylococcus aureus and Escherichia coli strains. Both low molecular weight and high molecular weight chitosan formulations showed similar antimicrobial behaviour. Hydrogel formulation with citric acid buffer possessed strong buffering capability in simulated wound fluid (SWF) which is important for maintaining an acidic wound milieu microenvironment. In vitro study showed hydrogel treatment significantly increases cell metabolic activity which is indicative of a higher proliferative rate, hence faster re-epithelization which is integral for successful wound closure. Low molecular weight chitosan at a concentration of 3.5% w/v was found to possess the best profile for topical application on wound management showing excellent bioadhesion, viscosity, and spreadability on skin sample surface that is important for ensuring an easy and uniform application of the formulation on the wounded site.
Details
- Title
- Harnessing the benefits of utilizing the optimal pH in conjunction with a hydrogel for wound care
- Authors/Creators
- Pivian Sim - University of South AustraliaYunmei Song - University of South AustraliaSam Abraham - Murdoch UniversitySanjay Garg - University of South Australia
- Publication Details
- Journal of drug delivery science and technology, Vol.89, 105027
- Publisher
- Elsevier B.V.
- Identifiers
- 991005609669707891
- Copyright
- © 2023 The Authors.
- Murdoch Affiliation
- Murdoch University; Antimicrobial Resistance and Infectious Disease Laboratory; Centre for Biosecurity and One Health; School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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