Journal article
Harnessing the potential of lung stem cells for regenerative medicine
The International Journal of Biochemistry & Cell Biology, Vol.56, pp.82-91
2014
Abstract
In response to recurrent exposure to environmental insults such as allergens, pollution, irritants, smoke and viral/bacterial infection, the epithelium of the lung is continually damaged. Homeostasis of the lung requires a balance between immune regulation and promotion of tissue regeneration, which requires the co-ordinated proliferation and differentiation of stem and progenitor cells. In this review we reflect on the current understanding of lung epithelial stem and progenitor cells and advocate a model hierarchy in which self-renewing multipotent lung epithelial stem cells give rise to lineage restricted progenitor cells that repopulate airway and alveolar epithelial cell lineages during homeostasis and repair. We also discuss the role of mesenchymal progenitor cells in maintaining the structural integrity of the lung and propose a model in which mesenchymal cells act as the quintessential architects of lung regeneration by providing molecular signals, such as FGF-10, to regulate the fate and specificity of epithelial stem and progenitor cells. Moreover, we discuss the current status and future prospects for translating lung stem cell therapies to the clinic to replace, repair, or regenerate diseased lung tissue. This article is part of a directed issue entitled: Regenerative Medicine: the challenge of translation.
Details
- Title
- Harnessing the potential of lung stem cells for regenerative medicine
- Authors/Creators
- J.L. McQualter (Author/Creator) - The University of MelbourneD. Anthony (Author/Creator) - The University of MelbourneS. Bozinovski (Author/Creator) - The University of MelbourneC.M. Prêle (Author/Creator) - Harry Perkins Institute of Medical ResearchG.J. Laurent (Author/Creator) - Harry Perkins Institute of Medical Research
- Publication Details
- The International Journal of Biochemistry & Cell Biology, Vol.56, pp.82-91
- Publisher
- Elsevier Limited
- Identifiers
- 991005541502807891
- Copyright
- © 2014 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.1057 Pulmonary Surfactant
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- ESI research areas
- Biology & Biochemistry