Heartworm adulticide treatment: A tropical perspective

Filipe Dantas-Torres; Jennifer Ketzis; Gabriela Pérez Tort; Andrei Daniel Mihalca; Gad Baneth; Domenico Otranto; Malaika Watanabe; Bui Khanh Linh; Tawin Inpankaew; Pablo Borrás; Sangaran Arumugam; Barend Louis Penzhorn; Adrian Patalinghug Ybañez; Peter Irwin; Rebecca J Traub

doi:10.1186/s13071-023-05690-8

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Heartworm adulticide treatment: A tropical perspective

Journal article

Open access

Peer reviewed

Heartworm adulticide treatment: A tropical perspective

Filipe Dantas-Torres, Jennifer Ketzis, Gabriela Pérez Tort, Andrei Daniel Mihalca, Gad Baneth, Domenico Otranto, Malaika Watanabe, Bui Khanh Linh, Tawin Inpankaew, Pablo Borrás, …

Parasites & vectors, Vol.16(1), 148

2023

DOI: https://doi.org/10.1186/s13071-023-05690-8

PMID: 37106364

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Abstract

Animals

Dirofilaria immitis

Dirofilariasis - drug therapy

Dirofilariasis - epidemiology

Dirofilariasis - prevention & control

Dog Diseases - drug therapy

Dog Diseases - parasitology

Dogs

Filaricides - therapeutic use

Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and the availability of melarsomine, and discuss alternatives for the management of heartworm infections in dogs.

Details

Title: Heartworm adulticide treatment: A tropical perspective
Authors/Creators: Filipe Dantas-Torres - Instituto Aggeu Magalhães, Fundação Oswaldo Cruz (Fiocruz), Recife, Pernambuco, Brazil. filipe.torres@fiocruz.br
Jennifer Ketzis - Ross University School of Veterinary Medicine
Gabriela Pérez Tort - Universidad de Buenos Aires
Andrei Daniel Mihalca - University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
Gad Baneth - The Hebrew University of Jerusalem, Rehovot, Israel
Domenico Otranto - University of Bari, Valenzano, Bari, Italy
Malaika Watanabe - University Putra Malaysia, Serdang, Selangor, Malaysia
Bui Khanh Linh - Vietnam National University of Agriculture, Hanoi, Vietnam
Tawin Inpankaew - Kasetsart University, Bangkok, Thailand
Pablo Borrás - Administración Nacional de Laboratorios e Institutos de Salud
Sangaran Arumugam - Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, India
Barend Louis Penzhorn - University of Pretoria, Pretoria, South Africa
Adrian Patalinghug Ybañez - Cebu Technological University
Peter Irwin - Murdoch University, School of Veterinary Medicine
Rebecca J Traub - The University of Melbourne
Publication Details: Parasites & vectors, Vol.16(1), 148
Publisher: BioMed Central Ltd as Part of Springer Nature.
Identifiers: 991005585968907891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.163 Parasitology - General; 1.163.1393 Filarial Infections
Web Of Science research areas: Parasitology; Tropical Medicine
ESI research areas: Microbiology