Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C

J.K. Olynyk; K.R. Reddy; A.M. di Bisceglie; L.J. Jeffers; T.I. Parker; J.L. Radick; E.R. Schiff; B.R. Bacon

doi:10.1016/0016-5085(95)90209-0

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Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C

Journal article

Peer reviewed

Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C

J.K. Olynyk, K.R. Reddy, A.M. di Bisceglie, L.J. Jeffers, T.I. Parker, J.L. Radick, E.R. Schiff and B.R. Bacon

Gastroenterology, Vol.108(4), pp.1104-1109

1995

DOI: https://doi.org/10.1016/0016-5085(95)90209-0

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Abstract

Background/Aims: It has been reported that hepatic iron concentration (HIC) may influence response to therapy in chronic viral hepatitis. The aim of this study was to determine the relationship between HIC and response to interferon alfa therapy in patients with chronic hepatitis C. Methods: HIC was measured in liver biopsy specimens from 58 patients with chronic hepatitis C treated at three centers. Three patients had mild chronic hepatitis C, 35 had moderate to severe chronic hepatitis C, and 20 had active cirrhosis. Serum ferritin levels were measured in 51 of these 58 patients. Response to therapy was defined as normalization of alanine aminotransferase levels at the end of treatment. Results: Twenty-four patients (41%) responded to therapy. HICs were generally within the normal range (<1500 μg/g). The mean HIC in nonresponders (860 ± 100 μg/g; range, 116–2296 μg/g) was significantly higher than in responders (548 ± 85 μg g; range, 29–1870 μg/g) (P < 0.05). Eighty-eight percent of patients with an HIC of >1100 μg/g and 87% of patients with an elevated serum ferritin concentration did not respond to interferon alfa therapy. Conclusions: HIC seems to influence response to interferon alfa therapy among patients with chronic hepatitis C. A subgroup of patients with chronic hepatitis C has been identified for which an HIC of >1100 μg/g predicted nonresponse in 88% of patients.

Details

Title: Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C
Authors/Creators: J.K. Olynyk (Author/Creator) - Saint Louis University
K.R. Reddy (Author/Creator) - University of Miami
A.M. di Bisceglie (Author/Creator) - National Institutes of Health
L.J. Jeffers (Author/Creator) - University of Miami
T.I. Parker (Author/Creator) - University of Miami
J.L. Radick (Author/Creator) - University of Miami
E.R. Schiff (Author/Creator) - University of Miami
B.R. Bacon (Author/Creator) - Saint Louis University
Publication Details: Gastroenterology, Vol.108(4), pp.1104-1109
Publisher: Elsevier
Identifiers: 991005544879307891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.184 Physiology & Metals; 1.184.573 Iron Metabolism
Web Of Science research areas: Gastroenterology & Hepatology
ESI research areas: Clinical Medicine