Journal article
Hepatitis C virus adaptation to T-cell immune pressure
The Scientific World Journal, Vol.2013, pp.1-7
2013
Abstract
Replication of the hepatitis C virus (HCV) is an error-prone process. This high error rate results in the emergence of viral populations (quasispecies) within hosts and contributes to interhost variability. Numerous studies have demonstrated that both viral and host factors contribute to this viral diversity, which can ultimately affect disease outcome. As the host's immune response is an important correlate of infection outcome for HCV, many of these viral variations are strongly influenced by T-cell immune pressure and accordingly constitute an efficient strategy to subvert such pressures (viral adaptations). This paper will review the data on viral diversity observed between and within hosts infected with HCV from the acute to the chronic stage of infection and will focus on viral adaptation to the host's T-cell immune response.
Details
- Title
- Hepatitis C virus adaptation to T-cell immune pressure
- Authors/Creators
- A. Plauzolles (Author/Creator) - The University of Western AustraliaM. Lucas (Author/Creator) - Murdoch UniversityS. Gaudieri (Author/Creator) - School of Anatomy, Physiology and Human Biology
- Publication Details
- The Scientific World Journal, Vol.2013, pp.1-7
- Publisher
- Hindawi Publishing Corporation
- Identifiers
- 991005544176407891
- Copyright
- © 2013 A. Plauzolles et al.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
- Note
- This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.83 HCV
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Immunology