Hepatitis E virus is prevalent in the pig population of Lao People's Democratic Republic and evidence exists for homogeneity with Chinese Genotype 4 human isolates

J. Conlan; R.G. Jarman; K. Vongxay; P. Chinnawirotpisan; M.C. Melendrez; S. Fenwick; R.C.A. Thompson; S.D. Blacksell

doi:10.1016/j.meegid.2011.04.022

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Hepatitis E virus is prevalent in the pig population of Lao People's Democratic Republic and evidence exists for homogeneity with Chinese Genotype 4 human isolates

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Hepatitis E virus is prevalent in the pig population of Lao People's Democratic Republic and evidence exists for homogeneity with Chinese Genotype 4 human isolates

J. Conlan, R.G. Jarman, K. Vongxay, P. Chinnawirotpisan, M.C. Melendrez, S. Fenwick, R.C.A. Thompson and S.D. Blacksell

Infection, Genetics and Evolution, Vol.11(6), pp.1306-1311

2011

DOI: https://doi.org/10.1016/j.meegid.2011.04.022

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Abstract

The objective of this study was to determine the prevalence and genotypic range of Hepatitis E virus (HEV) in the pig population of northern Lao People's Democratic Republic (PDR). We collected 181 faecal samples from indigenous-breed pigs ≤6 months of age and the faeces was stored in RNA stabilisation buffer due to cold-chain and transport limitations. Twenty-one (11.6%) pigs had detectable HEV RNA and 43.5% of village pig herds were infected. Based on a 240 base pair-nucleotide sequence flanking the junction of open reading frames 1, 2 and 3 (ORF1, ORF2 and ORF3) the isolates were phylogenetically classified within genotype 4. Phylogenetic analyses revealed distinct genetic groupings of the Lao HEV isolates and two groups clustered with human and pig HEV isolates from China. This was the first study to demonstrate genotype 4 HEV in Lao PDR and indicates pigs are a potential reservoir for human HEV infection.

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Title: Hepatitis E virus is prevalent in the pig population of Lao People's Democratic Republic and evidence exists for homogeneity with Chinese Genotype 4 human isolates
Authors/Creators: J. Conlan (Author/Creator) - Murdoch University
R.G. Jarman (Author/Creator) - Armed Forces Research Institute of Medical Science
K. Vongxay (Author/Creator) - Ministry of Agriculture and Forestry
P. Chinnawirotpisan (Author/Creator) - Armed Forces Research Institute of Medical Science
M.C. Melendrez (Author/Creator) - Armed Forces Research Institute of Medical Science
S. Fenwick (Author/Creator) - Murdoch University
R.C.A. Thompson (Author/Creator) - Murdoch University
S.D. Blacksell (Author/Creator) - Angkor Hospital for Children
Publication Details: Infection, Genetics and Evolution, Vol.11(6), pp.1306-1311
Publisher: Elsevier BV
Identifiers: 991005542611307891
Copyright: © 2011 Elsevier B.V.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.125 Hepatitis; 1.125.1718 Hepatitis A and E
Web Of Science research areas: Infectious Diseases
ESI research areas: Molecular Biology & Genetics