Journal article
Hepatotoxicosis in dogs consuming a diet of camel meat contaminated with indospicine
Australian Veterinary Journal, Vol.89(3), pp.95-100
2011
Abstract
Background: Four dogs presented with clinical signs of severe hepatic disease after consuming a commercial camel meat diet. Methods: Laboratory investigation revealed evidence of severe liver disease, including markedly increased serum alanine aminotransferase (ALT) activity and total bilirubin concentration, and prolonged clotting times. Results: Two dogs deteriorated despite supportive therapy and were euthanased. Histologically, both livers appeared similar, with the main lesion being extensive periacinar necrosis and haemorrhage. Indospicine, a toxic amino acid of plant origin, was detected in the serum and/or plasma from all four dogs, as well as in tissues of a dog that was necropsied and in a sample of the camel meat fed to this animal. Serum biochemistry tests using blood samples collected from 15 additional dogs identified as having eaten the diet detected indospicine was in the serum of 14 and 3 had increased ALT activity. One of the latter dogs subsequently developed clinical signs of severe liver disease and was euthanased. Conclusion: To the authors' knowledge, this is the first published report of the detection of indospicine residues in camel meat and the occurrence of severe, sometimes fatal, liver disease in dogs that consumed this contaminated meat.
Details
- Title
- Hepatotoxicosis in dogs consuming a diet of camel meat contaminated with indospicine
- Authors/Creators
- L. FitzGerald (Author/Creator) - Murdoch UniversityM.T. Fletcher (Author/Creator) - Department of Jobs and Small BusinessA.E.H. Paul (Author/Creator) - Murdoch UniversityC.S. Mansfield (Author/Creator) - Murdoch UniversityA.J. O'Hara (Author/Creator) - Murdoch University
- Publication Details
- Australian Veterinary Journal, Vol.89(3), pp.95-100
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005545202907891
- Copyright
- © 2011 The Authors. Australian Veterinary Journal
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.85 Food Science & Technology
- 3.85.1711 Legume Nutritional Biochemistry
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science