Journal article
Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load
Arthritis & Rheumatism, Vol.63(1), pp.286-294
2010
Abstract
OBJECTIVE:
To determine the frequency and character of arthropathy in hereditary hemochromatosis (HH) and to investigate the relationship between this arthropathy, nodal interphalangeal osteoarthritis, and iron load.
METHODS:
Participants were recruited from the community by newspaper advertisement and assigned to diagnostic confidence categories for HH (definite/probable or possible/unlikely). Arthropathy was determined by use of a predetermined clinical protocol, radiographs of the hands of all participants, and radiographs of other joints in which clinical criteria were met.
RESULTS:
An arthropathy considered typical for HH, involving metacarpophalangeal joints 2-5 and bilateral specified large joints, was observed in 10 of 41 patients with definite or probable HH (24%), all of whom were homozygous for the C282Y mutation in the HFE gene, while only 2 of 62 patients with possible/unlikely HH had such an arthropathy (P=0.0024). Arthropathy in definite/probable HH was more common with increasing age and was associated with ferritin concentrations>1,000 μg/liter at the time of diagnosis (odds ratio 14.0 [95% confidence interval 1.30-150.89], P=0.03). A trend toward more episodes requiring phlebotomy was also observed among those with arthropathy, but this was not statistically significant (odds ratio 1.03 [95% confidence interval 0.99-1.06], P=0.097). There was no significant association between arthropathy in definite/probable HH and a history of intensive physical labor (P=0.12).
CONCLUSION:
An arthropathy consistent with that commonly attributed to HH was found to occur in 24% of patients with definite/probable HH. The association observed between this arthropathy, homozygosity for C282Y, and serum ferritin concentrations at the time of diagnosis suggests that iron load is likely to be a major determinant of arthropathy in HH and to be more important than occupational factors.
Details
- Title
- Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load
- Authors/Creators
- G.J. Carroll (Author/Creator) - Fremantle HospitalW.H. Breidahl (Author/Creator) - Royal Perth HospitalM.K. Bulsara (Author/Creator) - The University of Notre Dame AustraliaJ.K. Olynyk (Author/Creator) - The University of Western Australia
- Publication Details
- Arthritis & Rheumatism, Vol.63(1), pp.286-294
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005541278407891
- Copyright
- © 2011 by the American College of Rheumatology
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
331 File views/ downloads
96 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.184 Physiology & Metals
- 1.184.573 Iron Metabolism
- Web Of Science research areas
- Rheumatology
- ESI research areas
- Clinical Medicine