Abstract
The hyperlipidemic effect of a chronic high fructose diet has been well documented, however, whether increased physical activity (PA) may confer protection against these effects is yet to be determined.
PURPOSE: The purpose of this study was to determine the interaction between chronic high fructose consumption and PA levels on post-prandial lipemia in normal weight, recreationally active individuals.
METHODS: Twenty-two normal weight men and women (age: 21.18 ± .61, BMI = 22.54 ± .60 kg/m2) consumed an an ad libitum diet while ingestiong an additional 75g of fructose for 14 days on 2 occasions. During the 14 days, subjects maintained either low PA (4500steps/day) or high PA (12,500 steps/day). Prior to and at the conclusion of the intervention, subjects underwent a study day in which they were given a fructose-rich meal (600 calorie mixed meal (45% carbohydrate [7.3% fructose], 40% fat, and 15% protein)) in the morning after a 12 h overnight fast. Blood was sampled at baseline and for 6 h after the meal and analyzed for triglycerides (TG), very-low density lipoproteins (VLDL), and total cholesterol (TC). The postprandial effect of a high fructose diet was determined by calculating total area under the curve (AUC) for TC, VLDL and TG.
RESULTS: VLDL AUC significantly increased by 773.7±372.9 mg/dL × 6hr from pre to post intervention in the inactive group while the active group increased by only 265.8 ± 314 mg/dL × 6hr (p=.015). The inactive, fructose-fed group increased TC AUC by 2598.16 ± 1162 mg/dL × 6hr from pre to post intervention compared to the active group which TC AUC increase by 598.421±1520 mg/dL × 6hr, however, this was not significant (p=.228). There were no significant differences in TG AUC levels.
CONCLUSIONS: Physical activity seems to be protective against increases in post-prandial lipemia when fed a diet high in fructose.