High activated and memory cytotoxic T-cell responses to HTLV-1 in healthy carriers and patients with tropical spastic paraparesis

S. Daenke; A.G. Kermode; S.E. Hall; G. Taylor; J. Weber; S. Nightingale; C.R.M. Bangham

doi:10.1006/viro.1996.0101

Back

High activated and memory cytotoxic T-cell responses to HTLV-1 in healthy carriers and patients with tropical spastic paraparesis

Journal article

Peer reviewed

High activated and memory cytotoxic T-cell responses to HTLV-1 in healthy carriers and patients with tropical spastic paraparesis

S. Daenke, A.G. Kermode, S.E. Hall, G. Taylor, J. Weber, S. Nightingale and C.R.M. Bangham

Virology, Vol.217(1), pp.139-146

1996

DOI: https://doi.org/10.1006/viro.1996.0101

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

The cytotoxic T-lymphocyte (CTL) response to HTLV-1 is directed mainly against the Tax protein. Circulating, activated Tax-specific CTL can be found in a majority of healthy carriers and patients with the HTLV-1-associated disease tropical spastic paraparesis (HAM/TSP). In this study we present data on the Tax-specific CTL response of 26 HTLV-1 carriers, including 10 newly recruited subjects. Rex-specific CTL were not found in any subjects investigated. Activated and memory CTL responses were determined separately in 4 healthy carriers, 3 HAM/TSP patients, and 1 “seronegative HAM/TSP.” In all subjects, the mean frequency of peptide-specific memory cells per epitope (1/1307) was high. There was no significant difference in mean memory CTL frequency per epitope or in the proportion of subjects with activated CTL between healthy carriers and HAM/TSP patients. One individual with HAM/TSP had an unusually high frequency response to two peptides, suggesting immunodominance of epitope recognition in this individual. We conclude that the magnitude and components of the HTLV-1-specific CTL response do not differ between healthy carriers and HAM/TSP patients. These data do not support a specific CTL-mediated component in the pathogenesis of HAM/TSP.

Details

Title: High activated and memory cytotoxic T-cell responses to HTLV-1 in healthy carriers and patients with tropical spastic paraparesis
Authors/Creators: S. Daenke (Author/Creator) - John Radcliffe Hospital
A.G. Kermode (Author/Creator) - Department of Neurology and Clinical Neurophysiology, Sir Charles Gardner Hospital, Perth, Western Australia, 6009
S.E. Hall (Author/Creator) - Department of Immunology, St. Mary's Hospital Medical School, Norfolk Place, London, W2 1PG, United Kingdom
G. Taylor (Author/Creator) - St Mary's Hospital
J. Weber (Author/Creator) - St Mary's Hospital
S. Nightingale (Author/Creator) - Birmingham and Midland Eye Centre
C.R.M. Bangham (Author/Creator) - Department of Immunology, St. Mary's Hospital Medical School, Norfolk Place, London, W2 1PG, United Kingdom
Publication Details: Virology, Vol.217(1), pp.139-146
Publisher: Elsevier
Identifiers: 991005542416107891
Copyright: © 1996 Academic Press.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

20 Record Views

83 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.1464 HTLV-1/BLV Pathogenesis
Web Of Science research areas: Virology
ESI research areas: Microbiology