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Journal article
High prevalence and indexes of anti-John Cunningham virus antibodies in a cohort of Chinese patients with multiple sclerosis
Multiple sclerosis journal - experimental, translational and clinical, Vol.4(3)
2018
PMCID: PMC6050819
PMID: 30038791
Abstract
We performed a cross-sectional study in 123 Chinese multiple sclerosis patients residing in Hong Kong to evaluate their anti-John Cunningham virus status using STRATIFY JCV DxSelect assays. Anti-John Cunningham virus antibody was present in 98/123 (80%) subjects, among which 75/98 (77%) had an anti-John Cunningham virus index ≥1.5. Anti-John Cunningham virus antibody seropositivity was not correlated with age, disease duration, Expanded Disability Status Scale scores, types of multiple sclerosis (relapsing vs progressive), or disease-modifying treatments used. We found a very high seroprevalence and index of anti-John Cunningham virus antibodies in Chinese multiple sclerosis patients, which may impact the risk assessment and recommendation of disease-modifying treatments in this population.
Details
- Title
- High prevalence and indexes of anti-John Cunningham virus antibodies in a cohort of Chinese patients with multiple sclerosis
- Authors/Creators
- Alexander Lau - Department of Medicine and Therapeutics, Chinese University of Hong Kong, ChinaWei Qiu - Third Affiliated Hospital of Sun Yat-sen UniversityAllan Kermode - Perron Institute for Neurological and Translational ScienceCheryl Au - Department of Medicine and Therapeutics, Chinese University of Hong Kong, ChinaAngel Ng - Chinese University of Hong KongAdrian Wong - Chinese University of Hong KongSze-Ho Ma - Department of Medicine and Therapeutics, Chinese University of Hong Kong, ChinaLisa Au - Chinese University of Hong KongKaren Ma - Chinese University of Hong KongBonaventure Ip - Chinese University of Hong KongVincent Mok - Chinese University of Hong Kong
- Publication Details
- Multiple sclerosis journal - experimental, translational and clinical, Vol.4(3)
- Publisher
- SAGE Publications
- Identifiers
- 991005623566307891
- Copyright
- © The Author(s) 2018
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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