Journal article
High-resolution HLA-DRB1 genotyping in an Australian inclusion body myositis (s-IBM) cohort: An analysis of disease-associated alleles and diplotypes
Journal of Neuroimmunology, Vol.250(1-2), pp.77-82
2012
Abstract
We performed high-resolution (4-digit) HLA-DRB1 genotyping in an Australian cohort of 105s-IBM patients and 189 controls. Our findings showed that whilst the strongest association was with the HLA-DRB1*03:01 allele and the HLA-DRB1*03:01/*01:01 diplotype, HLA-DRB1*01:01 and HLA-DRB1*13:01 are also risk alleles. A number of other alleles, HLA-DRB1*04:01, *04:04, *07:01, *09:01, *11:01 and *15:01, as well as the HLA-DRB1*03:01/*04:01 and HLA-DRB1*03:01/*07:01 diplotypes were reduced in s-IBM cases and may be protective. The HLA-DRB1*03:01 and HLA-DRB1*13:01 alleles also appear to have an influence on the age at onset of the disease and severity of muscle weakness. Our findings indicate that the influence of HLA-DRB1 in s-IBM is complex and that epistatic interactions at the HLA-DRB1 locus contribute both to disease susceptibility and to the clinical phenotype.
Details
- Title
- High-resolution HLA-DRB1 genotyping in an Australian inclusion body myositis (s-IBM) cohort: An analysis of disease-associated alleles and diplotypes
- Authors/Creators
- A. Rojana-udomsart (Author/Creator)I. James (Author/Creator)A. Castley (Author/Creator)M. Needham (Author/Creator)A. Scott (Author/Creator)T. Day (Author/Creator)L. Kiers (Author/Creator)A. Corbett (Author/Creator)C. Sue (Author/Creator)C. Witt (Author/Creator)P. Martinez (Author/Creator)F. Christiansen (Author/Creator)F. Mastaglia (Author/Creator)
- Publication Details
- Journal of Neuroimmunology, Vol.250(1-2), pp.77-82
- Publisher
- Elsevier
- Identifiers
- 991005542500407891
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics; Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Immunology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior