Journal article
Histological and functional comparisons of four anatomical regions of porcine skin with human abdominal skin
Anatomia, Histologia, Embryologia, Vol.48(3), pp.207-217
2019
Abstract
Because of the shortage of human skin for research purposes, porcine skin has been used as a model of human skin. The aim of this study was to identify the region of German Landrace pig skin that could be used as the best possible substitute for human abdominal skin. Porcine samples were collected from the ear, flank, back and caudal abdomen; human abdominal skin samples were excised during plastic surgery. Histological and ultrastructural assessments were carried out on the epidermis and dermis, with emphasis on the dermo-epidermal interface length, dermo-epidermal thickness ratio as well as densities of; hair follicles, arrector pili muscles, blood vessels and sweat glands. In the pig, the barrier function of the four anatomical regions was assessed. Results showed that both histologically and ultrastructurally, all four regions of porcine skin were similar to human skin. These include the shapes of keratinocytes, structure of cell contacts and presence of Weibel Palade bodies in endothelial cells. Other parameters such as the thickness of epidermis, the thickness of stratum basale, spinosum and granulosum and the number of cell layers in the stratum corneum were similar in human abdominal and in all four regions of porcine skin. However, there were also significant differences especially in the thickness of the stratum corneum, the dermo-epidermal interface length and the blood vessel density.
Details
- Title
- Histological and functional comparisons of four anatomical regions of porcine skin with human abdominal skin
- Authors/Creators
- M. Khiao In (Author/Creator)K.C. Richardson (Author/Creator) - Murdoch UniversityA. Loewa (Author/Creator) - Freie Universität BerlinS. Hedtrich (Author/Creator) - Freie Universität BerlinS. Kaessmeyer (Author/Creator) - Freie Universität BerlinJ. Plendl (Author/Creator) - Freie Universität Berlin
- Publication Details
- Anatomia, Histologia, Embryologia, Vol.48(3), pp.207-217
- Publisher
- Blackwell Publishing Ltd
- Identifiers
- 991005545111307891
- Copyright
- © 2019 Blackwell Verlag GmbH
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
61 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.176 Drug Delivery Chemistry
- 2.176.771 Transdermal Delivery
- Web Of Science research areas
- Anatomy & Morphology
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science