Journal article
Homocystinuria: The effect of pyridoxine supplementation on cultured skin fibroblasts
Journal of Inherited Metabolic Disease, Vol.4(1), pp.7-9
1981
Abstract
Six skin fibroblast cultures, two derived from pyridoxine responsive homocystinurics, two from pyridoxine non-responsive homocystinurics, one from an obligate heterozygote and one from a normal control were grown for three passages in the presence of 9.7 µmol/l, 243 µmol/l and 486 µmol/l of pyridoxine respectively. Cystathionine β-synthase activity was stimulated in all four homocystinuric cell strains at 486 µmol/l; aspartate and alanine aminotransferase activity was also increased, particularly in the pyridoxine responsive cell strains. There was, however, evidence of cytotoxicity at the pyridoxine levels of 243 µmol/l and 486 µmol/l.
Details
- Title
- Homocystinuria: The effect of pyridoxine supplementation on cultured skin fibroblasts
- Authors/Creators
- A.H. Bittles (Author/Creator) - Queen's University BelfastN.A.J. Carson (Author/Creator) - Queen's University Belfast
- Publication Details
- Journal of Inherited Metabolic Disease, Vol.4(1), pp.7-9
- Publisher
- Kluwer Academic Publishers
- Identifiers
- 991005541188207891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.231 Vitamin Metabolism
- 1.231.432 Folate Metabolism
- Web Of Science research areas
- Endocrinology & Metabolism
- Genetics & Heredity
- Medicine, Research & Experimental
- ESI research areas
- Biology & Biochemistry