Journal article
Host genetic determinants of spontaneous hepatitis C clearance
Pharmacogenomics, Vol.10(11), pp.1819-1837
2009
Abstract
Acute infection with the hepatitis C virus (HCV) induces a wide range of innate and adaptive immune responses. A total of 20-50% of acutely HCV-infected individuals permanently control the virus, referred to as 'spontaneous hepatitis C clearance', while the infection progresses to chronic hepatitis C in the majority of cases. Numerous studies have examined host genetic determinants of hepatitis C infection outcome and revealed the influence of genetic polymorphisms of human leukocyte antigens, killer immunoglobulin-like receptors, chemokines, interleukins and interferon-stimulated genes on spontaneous hepatitis C clearance. However, most genetic associations were not confirmed in independent cohorts, revealed opposing results in diverse populations or were limited by varying definitions of hepatitis C outcomes or small sample size. Coordinated efforts are needed in the search for key genetic determinants of spontaneous hepatitis C clearance that include well-conducted candidate genetic and genome-wide association studies, direct sequencing and follow-up functional studies.
Details
- Title
- Host genetic determinants of spontaneous hepatitis C clearance
- Authors/Creators
- A. Rauch (Author/Creator) - University Hospital of BernS. Gaudieri (Author/Creator) - Royal Perth HospitalC. Thio (Author/Creator) - Johns Hopkins UniversityP-Y Bochud (Author/Creator) - University of Lausanne
- Publication Details
- Pharmacogenomics, Vol.10(11), pp.1819-1837
- Publisher
- Ashley Publications Ltd.
- Identifiers
- 991005542636907891
- Copyright
- © 2009 Future Medicine Ltd.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.83 HCV
- Web Of Science research areas
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology