Journal article
How lifestyle shapes the brain: Associations between physical activity, sleep, beta‐amyloid and cognitive function in older adults
Alzheimer's & Dementia, Vol.17(S6), e051223
2021
Abstract
Background
Lifestyle factors such as sleep and physical activity influence risk of cognitive decline and dementia. Higher habitual physical activity and optimal sleep are associated with better cognitive function and lower levels of Alzheimer’s disease biomarkers, including beta-amyloid (Aß). There is currently a poor understanding of how physical activity may influence the relationship between sleep and cognition, and whether exercise and sleep interact to influence cognition and Aß. Developing this understanding is crucial for creating effective lifestyle interventions for dementia prevention.
Method
Data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study were utilised to determine whether self-reported physical activity moderates the cross-sectional relationship between self-reported sleep parameters (duration, efficiency, latency, disturbance, quality), cognitive function (episodic memory, attention and processing speed, executive function), and brain Aß (quantified by amyloid positron emission tomography, using the Centiloid scale). Analyses were adjusted for age, sex, APOE ε4 carriage, mood, premorbid intelligence, and collection point. Participants were 404 community-dwelling cognitively normal older adults aged 60 and above (75.3 5.7 years). Data from a subset of participants (n = 220, aged 75.2 5.6 years) were used for analyses with AB as the outcome.
Result
Physical activity moderated the relationship between sleep duration and episodic memory (ß = -.09, SE = .03, p = .005), and sleep efficiency and episodic memory (ß = -.08, SE = .03, p = .016). Physical activity moderated the relationship between sleep duration and A® (ß = -.12, SE = .06, p = .036), and sleep quality and Aß (ß = .12, SE = .06, p = .029).
Conclusion
Physical activity may play an important role in the relationship between sleep and cognitive function, and sleep and brain Aß. Future longitudinal and intervention studies in this area are crucial for informing interventions for dementia prevention.
Details
- Title
- How lifestyle shapes the brain: Associations between physical activity, sleep, beta‐amyloid and cognitive function in older adults
- Authors/Creators
- Kelsey R Sewell - Murdoch University Perth WA AustraliaStephanie R Rainey-Smith - Murdoch University, Centre for Healthy AgeingVictor LL Villemagne - University of PittsburghJeremiah J Peiffer - Murdoch University, Centre for Healthy AgeingHamid R Sohrabi - Murdoch University, Centre for Healthy AgeingKevin Taddei - Australian Alzheimer’s Research FoundationDavid Ames - The University of MelbournePaul T Maruff - Florey Institute of Neuroscience and Mental HealthSimon M Laws - Edith Cowan UniversityColin L Masters - Florey Institute of Neuroscience and Mental HealthChristopher C Rowe - Florey Institute of Neuroscience and Mental HealthRalph N Martins - KaRaMindsKirk I. Erickson - University of PittsburghBelinda M Brown - Murdoch University, Centre for Healthy Ageing
- Publication Details
- Alzheimer's & Dementia, Vol.17(S6), e051223
- Identifiers
- 991005609567407891
- Copyright
- © 2021 The Alzheimer’s Association
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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