How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers

Chiara Ferrario; Rosario Statello; Luca Carnevali; Leonardo Mancabelli; Christian Milani; Marta Mangifesta; Sabrina Duranti; Gabriele A. Lugli; Beatriz Jimenez; Sam L Lodge; Alice Viappiani; Giulia Alessandri; Margerita Dall’Asta; Daniele Del Rio; Andrea Sgoifo; Douwe van Sinderen; Marco Ventura; Francesca Turroni

doi:10.3389/fmicb.2017.01749

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How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers

Journal article

Open access

Peer reviewed

How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers

Chiara Ferrario, Rosario Statello, Luca Carnevali, Leonardo Mancabelli, Christian Milani, Marta Mangifesta, Sabrina Duranti, Gabriele A. Lugli, Beatriz Jimenez, Sam L Lodge, …

Frontiers in microbiology, Vol.8, 1749

2017

DOI: https://doi.org/10.3389/fmicb.2017.01749

PMID: 28955319

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Abstract

acetate

diet

dietary fibers

Microbiology

microbiota

rat model

succinate

The composition of the gut microbiota of mammals is greatly influenced by diet. Therefore, evaluation of different food ingredients that may promote changes in the gut microbiota composition is an attractive approach to treat microbiota disturbances. In this study, three dietary fibers, such as inulin (I, 10%), resistant starch (RS, 10%), and citrus pectin (3%), were employed as supplements to normal chow diet of adult male rats for 2 weeks. Fecal microbiota composition and corresponding metabolite profiles were assessed before and after prebiotics supplementation. A general increase in the Bacteroidetes phylum was detected with a concurrent reduction in Firmicutes, in particular for I and RS experiments, while additional changes in the microbiota composition were evident at lower taxonomic levels for all the three substrates. Such modifications in the microbiota composition were correlated with changes in metabolic profiles of animals, in particular changes in acetate and succinate levels. This study represents a first attempt to modulate selectively the abundance and/or metabolic activity of various members of the gut microbiota by means of dietary fiber.

Details

Title: How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers
Authors/Creators: Chiara Ferrario - Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Rosario Statello - Stress Physiology Laboratory, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Luca Carnevali - Stress Physiology Laboratory, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Leonardo Mancabelli - Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Christian Milani - Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Marta Mangifesta - GenProbio s.r.l
Sabrina Duranti - Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Gabriele A. Lugli - Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Beatriz Jimenez - Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London
Sam L Lodge
Alice Viappiani - GenProbio s.r.l
Giulia Alessandri - Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Margerita Dall’Asta - Department of Food and Drug, University of Parma
Daniele Del Rio - Department of Food and Drug, University of Parma
Andrea Sgoifo - Stress Physiology Laboratory, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Douwe van Sinderen - APC Microbiome Institute and School of Microbiology, National University of Ireland
Marco Ventura - Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Francesca Turroni - Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
Publication Details: Frontiers in microbiology, Vol.8, 1749
Publisher: Frontiers Media S.A
Identifiers: 991005587769207891
Murdoch Affiliation: Centre for Computational and Systems Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.120 Inflammatory Bowel Diseases & Infections; 1.120.384 Gut Microbiota
Web Of Science research areas: Microbiology
ESI research areas: Microbiology