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CC BY V4.0, Open Access
Journal article
Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation
Nutrients, Vol.10(8), 1125
2018
PMCID: PMC6115716
PMID: 30127292
Abstract
Human milk (HM) adipokines may influence infant feeding patterns, appetite regulation, and body composition (BC). The associations between concentrations/calculated daily intakes (CDI) of HM adipokines in the first 12 months postpartum and maternal/term infant BC, and infant breastfeeding parameters were investigated. BC of breastfeeding dyads (n = 20) was measured at 2, 5, 9, and/or 12 months postpartum with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers). 24-h milk intake and feeding frequency were measured along with whole milk adiponectin and skim and whole milk leptin (SML and WML) and CDI were calculated. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Adipokine concentrations did not associate with infant BC. Higher CDI of adiponectin were associated with lower infant fat-free mass (FFM; p = 0.005) and FFM index (FFMI; p = 0.009) and higher fat mass (FM; p < 0.001), FM index (FMI; p < 0.001), and %FM (p < 0.001). Higher CDI of SML were associated with higher infant FM (p < 0.001), FMI (p < 0.001), and %FM (p = 0.002). At 12 months, higher CDI of WML were associated with larger increases in infant adiposity (2-12 month: FM, p = 0.0006; %FM, p = 0.0004); higher CDI of SML were associated with a larger decrease in FFMI (5-12 months: p = 0.0004). Intakes of HM adipokines differentially influence development of infant BC in the first year of life, which is a critical window of infant programming and may potentially influence risk of later disease via modulation of BC.
Details
- Title
- Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation
- Authors/Creators
- Zoya Gridneva - The University of Western AustraliaSambavi Kugananthan - The University of Western AustraliaAlethea Rea - The University of Western AustraliaChing Tat Lai - The University of Western AustraliaLeigh C. Ward - The University of QueenslandKevin Murray - The University of Western AustraliaPeter E. Hartmann - The University of Western AustraliaDonna T. Geddes - The University of Western Australia
- Publication Details
- Nutrients, Vol.10(8), 1125
- Publisher
- MDPI
- Number of pages
- 24
- Grant note
- Margaret Lomann-Hall Scholarship from School of Human Sciences, The University of Western Australia (Australia) Medela AG (Switzerland) Australian Postgraduate Award from University of Western Australia (Australia)
- Identifiers
- 991005580052907891
- Copyright
- © 2018 by the authors.
- Murdoch Affiliation
- School of Mathematics, Statistics, Chemistry and Physics; Centre for Terrestrial Ecosystem Science and Sustainability
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.891 Breastfeeding
- Web Of Science research areas
- Nutrition & Dietetics
- ESI research areas
- Agricultural Sciences