Human milk immunomodulatory proteins are related to development of infant body composition during the first year of lactation

Z. Gridneva; C.T. Lai; A. Rea; W.J. Tie; L.C. Ward; K. Murray; P.E. Hartmann; D.T. Geddes

doi:10.1038/s41390-020-0961-z

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Human milk immunomodulatory proteins are related to development of infant body composition during the first year of lactation

Journal article

Peer reviewed

Human milk immunomodulatory proteins are related to development of infant body composition during the first year of lactation

Z. Gridneva, C.T. Lai, A. Rea, W.J. Tie, L.C. Ward, K. Murray, P.E. Hartmann and D.T. Geddes

Pediatric Research

2020

DOI: https://doi.org/10.1038/s41390-020-0961-z

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Abstract

Background To investigate relationships between infant body composition (BC) and human milk (HM) immunomodulatory proteins (IMPs) during the first 12 months of lactation. Methods BC of breastfeeding dyads (n = 20) was measured with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers) at 2, 5, 9, and/or 12 months post partum. Breastfeeding frequency, 24-h milk intake, and IMP concentrations (lactoferrin, lysozyme, secretory immunoglobulin A (sIgA)) were measured, and calculated daily intakes (CDIs) were determined. We used linear regression/mixed-effects models and adjusted results for multiple comparisons. Results No associations were seen between maternal characteristics and IMP concentrations/CDIs or between IMP concentrations and infant BC. Lactoferrin CDI was negatively associated with infant fat-free mass index (P = 0.002); lysozyme CDI was positively associated with infant fat mass (P = 0.004) and fat mass index (P = 0.004) measured with ultrasound skinfolds. Conclusion In this small cohort of infants breastfed on demand during first year of life, we report differential associations of HM IMPs with infant BC, showing that in addition to their critical role in shaping infant immunity, lactoferrin, and lysozyme also influence development of infant BC, highlighting the importance of breastfeeding for 12 months and beyond.

Details

Title: Human milk immunomodulatory proteins are related to development of infant body composition during the first year of lactation
Authors/Creators: Z. Gridneva (Author/Creator) - The University of Western Australia
C.T. Lai (Author/Creator) - The University of Western Australia
A. Rea (Author/Creator) - Murdoch University
W.J. Tie (Author/Creator) - The University of Western Australia
L.C. Ward (Author/Creator) - The University of Queensland
K. Murray (Author/Creator) - The University of Western Australia
P.E. Hartmann (Author/Creator) - The University of Western Australia
D.T. Geddes (Author/Creator) - The University of Western Australia
Publication Details: Pediatric Research
Publisher: Lippincott Williams & Wilkins Ltd
Identifiers: 991005545337307891
Copyright: © 2020 Springer Nature Limited
Murdoch Affiliation: Information Technology, Mathematics and Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.72 Obstetrics & Gynecology; 1.72.891 Breastfeeding
Web Of Science research areas: Pediatrics
ESI research areas: Clinical Medicine