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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Human milk macronutrients and bioactive molecules and development of regional fat depots in Western Australian infants during the first 12 months of lactation
Life, Vol.12(4), Article 493
2022
Abstract
We investigated associations between intakes of human milk (HM) components (macronutrients and biologically active molecules) and regional fat depots development in healthy term infants (n = 20) across the first year of lactation. Infant limb (mid-arm and mid-thigh) lean and fat areas were assessed by ultrasound imaging at 2, 5, 9 and 12 months of age. Concentrations of HM total protein, whey protein, casein, adiponectin, leptin, lysozyme, lactoferrin, secretory IGA, total carbohydrates, lactose, HM oligosaccharides (total HMO, calculated) and infant 24-h milk intake were measured, and infant calculated daily intakes (CDI) of HM components were determined. This pilot study shows higher 24-h milk intake was associated with a larger mid-arm fat area (p = 0.024), higher breastfeeding frequency was associated with larger mid-arm (p = 0.008) and mid-thigh (p < 0.001) fat areas. Lysozyme (p = 0.001) and HMO CDI (p = 0.004) were time-dependently associated with the mid-arm fat area. Intakes of HM components and breastfeeding parameters may modulate infant limb fat depots development during the first year of age and potentially promote favorable developmental programming of infant body composition; however, further studies are needed to confirm these findings.
Details
- Title
- Human milk macronutrients and bioactive molecules and development of regional fat depots in Western Australian infants during the first 12 months of lactation
- Authors/Creators
- Z. Gridneva (Author/Creator)A. Rea (Author/Creator)C.T. Lai (Author/Creator)Wan Jun Tie (Author/Creator)S. Kugananthan (Author/Creator)A.H. Warden (Author/Creator)S.L. Perrella (Author/Creator)K. Murray (Author/Creator)D.T. Geddes (Author/Creator)
- Publication Details
- Life, Vol.12(4), Article 493
- Publisher
- MDPI
- Identifiers
- 991005540292707891
- Copyright
- © 2022 by the authors
- Murdoch Affiliation
- Information Technology, Mathematics and Statistics
- Language
- English
- Resource Type
- Journal article
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- Microbiology
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