Journal article
Human population structure, genome autozygosity and human health
Genome Medicine, Vol.1(9)
2009
Abstract
A major transition in human population structure is currently under way, moving from a historical metapopulation, comprising small and mainly rural endogamous communities, to large and increasingly panmictic urban populations. This process is predicted to increase outbreeding, and preliminary data from genomic surveys have helped to quantify the potential magnitude of the effects. Population genetic trends of this nature should result in a reduced burden of recessive disorders, and have a favourable impact on complex diseases influenced by partially recessive genetic variants of smaller effect. The overall outcome is expected to be beneficial for a range of traits associated with human health and disease that show dominance variance.
Details
- Title
- Human population structure, genome autozygosity and human health
- Authors/Creators
- H. Campbell (Author/Creator) - University of EdinburghI. Rudan (Author/Creator) - University of EdinburghA.H. Bittles (Author/Creator) - Murdoch UniversityA.F. Wright (Author/Creator) - Institute of Genetics and Cancer
- Publication Details
- Genome Medicine, Vol.1(9)
- Publisher
- BioMed Central
- Identifiers
- 991005543760607891
- Copyright
- © 2009 BioMed Central Ltd
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.189 Genome Studies
- 1.189.1853 Human Genetic Diversity
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics