Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

T. Guadalupe; S.R. Mathias; T.G.M. vanErp; C.D. Whelan; M.P. Zwiers; Y. Abe; L. Abramovic; I. Agartz; O.A. Andreassen; A. Arias-Vasquez; B.S. Aribisala; N.J. Armstrong; V. Arolt; E. Artiges; R. Ayesa-Arriola; V.G. Baboyan; T. Banaschewski; G. Barker; M.E. Bastin; B.T. Baune; J. Blangero; A.L.W. Bokde; P.S.W. Boedhoe; A. Bose; S. Brem; H. Brodaty; U. Bromberg; S. Brooks; C. Büchel; J. Buitelaar; V.D. Calhoun; D.M. Cannon; A. Cattrell; Y. Cheng; P.J. Conrod; A. Conzelmann; A. Corvin; B. Crespo-Facorro; F. Crivello; U. Dannlowski; G.I. de Zubicaray; S.M.C. de Zwarte; I.J. Deary; S. Desrivières; N.T. Doan; G. Donohoe; E.S. Dørum; S. Ehrlich; T. Espeseth; G. Fernández; H. Flor; J-P Fouche; V. Frouin; M. Fukunaga; J. Gallinat; H. Garavan; M. Gill; A.G. Suarez; P. Gowland; H.J. Grabe; D. Grotegerd; O. Gruber; S. Hagenaars; R. Hashimoto; T.U. Hauser; A. Heinz; D.P. Hibar; P.J. Hoekstra; M. Hoogman; F.M. Howells; H. Hu; H.E. Hulshoff Pol; C. Huyser; B. Ittermann; N. Jahanshad; E.G. Jönsson; S. Jurk; R.S. Kahn; S. Kelly; B. Kraemer; H. Kugel; J.S. Kwon; H. Lemaitre; K-P Lesch; C. Lochner; M. Luciano; A.F. Marquand; N.G. Martin; I. Martínez-Zalacaín; J-L Martinot; D. Mataix-Cols; K. Mather; C. McDonald; K.L. McMahon; S.E. Medland; J.M. Menchón; D.W. Morris; O. Mothersill; S.M. Maniega; B. Mwangi; T. Nakamae; T. Nakao; J.C. Narayanaswaamy; F. Nees; J.E. Nordvik; A.M.H. Onnink; N. Opel; R. Ophoff; M-L Paillère Martinot; D. Papadopoulos Orfanos; P. Pauli; T. Paus; L. Poustka; J.YC. Reddy; M.E. Renteria; R. Roiz-Santiáñez; A. Roos; N.A. Royle; P. Sachdev; P. Sánchez-Juan; L. Schmaal; G. Schumann; E. Shumskaya; M.N. Smolka; J.C. Soares; C. Soriano-Mas; D.J. Stein; L.T. Strike; R. Toro; J.A. Turner; N. Tzourio-Mazoyer; A. Uhlmann; M.V. Hernández; O.A. van den Heuvel; D. van der Meer; N.E.M . van Haren; D.J. Veltman; G. Venkatasubramanian; N.C. Vetter; D. Vuletic; S. Walitza; H. Walter; E. Walton; Z. Wang; J. Wardlaw; W. Wen; L.T. Westlye; R. Whelan; K. Wittfeld; T. Wolfers; M.J. Wright; J. Xu; X. Xu; J-Y Yun; J.J. Zhao; B. Franke; P.M. Thompson; D.C. Glahn; B. Mazoyer; S.E. Fisher; C. Francks

doi:10.1007/s11682-016-9629-z

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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

T. Guadalupe, S.R. Mathias, T.G.M. vanErp, C.D. Whelan, M.P. Zwiers, Y. Abe, L. Abramovic, I. Agartz, O.A. Andreassen, A. Arias-Vasquez, …

Brain Imaging and Behavior, Vol.11(5), pp.1497-1514

2016

DOI: https://doi.org/10.1007/s11682-016-9629-z

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Abstract

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

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Title: Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
Authors/Creators: T. Guadalupe (Author/Creator) - Max Planck Society
S.R. Mathias (Author/Creator) - Yale University
T.G.M. vanErp (Author/Creator) - University of California, Irvine
C.D. Whelan (Author/Creator) - University of Southern California
M.P. Zwiers (Author/Creator) - Radboud University Nijmegen
Y. Abe (Author/Creator) - Kyoto Prefectural University of Medicine
L. Abramovic (Author/Creator) - Utrecht University
I. Agartz (Author/Creator) - Karolinska Institutet
O.A. Andreassen (Author/Creator) - University of Oslo
A. Arias-Vasquez (Author/Creator) - Radboud University Nijmegen
B.S. Aribisala (Author/Creator) - University of Edinburgh
N.J. Armstrong (Author/Creator) - UNSW Sydney
V. Arolt (Author/Creator) - University of Münster
E. Artiges (Author/Creator) - Université Paris-Sud
R. Ayesa-Arriola (Author/Creator)
V.G. Baboyan (Author/Creator) - University of Southern California
T. Banaschewski (Author/Creator) - Heidelberg University
G. Barker (Author/Creator) - University College London
M.E. Bastin (Author/Creator) - University of Edinburgh
B.T. Baune (Author/Creator) - The University of Adelaide
J. Blangero (Author/Creator) - The University of Texas at Austin
A.L.W. Bokde (Author/Creator) - Trinity College Dublin
P.S.W. Boedhoe (Author/Creator) - Vrije Universiteit Amsterdam
A. Bose (Author/Creator) - National Institute of Mental Health and Neurosciences
S. Brem (Author/Creator) - University of Zurich
H. Brodaty (Author/Creator) - UNSW Sydney
U. Bromberg (Author/Creator) - Universität Hamburg
S. Brooks (Author/Creator) - University of Cape Town
C. Büchel (Author/Creator) - Universität Hamburg
J. Buitelaar (Author/Creator) - Radboud University Nijmegen
V.D. Calhoun (Author/Creator) - University of New Mexico
D.M. Cannon (Author/Creator) - Ollscoil na Gaillimhe – University of Galway
A. Cattrell (Author/Creator) - Medical Research Council
Y. Cheng (Author/Creator) - Kunming Medical University
P.J. Conrod (Author/Creator) - Université de Montréal
A. Conzelmann (Author/Creator) - University of Tübingen
A. Corvin (Author/Creator) - Trinity College Dublin
B. Crespo-Facorro (Author/Creator)
F. Crivello (Author/Creator) - Université de Bordeaux
U. Dannlowski (Author/Creator) - University of Münster
G.I. de Zubicaray (Author/Creator) - Queensland University of Technology
S.M.C. de Zwarte (Author/Creator) - Utrecht University
I.J. Deary (Author/Creator) - University of Edinburgh
S. Desrivières (Author/Creator) - Medical Research Council
N.T. Doan (Author/Creator) - University of Oslo
G. Donohoe (Author/Creator) - Ollscoil na Gaillimhe – University of Galway
E.S. Dørum (Author/Creator) - University of Oslo
S. Ehrlich (Author/Creator) - Technische Universität Dresden
T. Espeseth (Author/Creator) - University of Oslo
G. Fernández (Author/Creator) - Radboud University Nijmegen
H. Flor (Author/Creator) - Heidelberg University
J-P Fouche (Author/Creator) - University of Cape Town
V. Frouin (Author/Creator) - Commissariat à l'Énergie Atomique et aux Énergies Alternatives
M. Fukunaga (Author/Creator) - National Institutes of Natural Sciences
J. Gallinat (Author/Creator) - Universität Hamburg
H. Garavan (Author/Creator) - University of Vermont
M. Gill (Author/Creator) - Trinity College Dublin
A.G. Suarez (Author/Creator)
P. Gowland (Author/Creator) - University of Nottingham
H.J. Grabe (Author/Creator) - Universitätsmedizin Greifswald
D. Grotegerd (Author/Creator) - University of Münster
O. Gruber (Author/Creator) - University of Göttingen
S. Hagenaars (Author/Creator) - University of Edinburgh
R. Hashimoto (Author/Creator) - The University of Osaka
T.U. Hauser (Author/Creator) - University College London
A. Heinz (Author/Creator) - Charité - Universitätsmedizin Berlin
D.P. Hibar (Author/Creator) - University of Southern California
P.J. Hoekstra (Author/Creator) - University of Groningen
M. Hoogman (Author/Creator) - Radboud University Nijmegen
F.M. Howells (Author/Creator) - University of Cape Town
H. Hu (Author/Creator) - Shanghai Jiao Tong University
H.E. Hulshoff Pol (Author/Creator)
C. Huyser (Author/Creator) - University of Amsterdam
B. Ittermann (Author/Creator) - Physikalisch-Technische Bundesanstalt
N. Jahanshad (Author/Creator) - University of Southern California
E.G. Jönsson (Author/Creator) - Karolinska Institutet
S. Jurk (Author/Creator) - Technische Universität Dresden
R.S. Kahn (Author/Creator) - Utrecht University
S. Kelly (Author/Creator) - University of Southern California
B. Kraemer (Author/Creator) - University of Göttingen
H. Kugel (Author/Creator) - University of Münster
J.S. Kwon (Author/Creator) - Seoul National University
H. Lemaitre (Author/Creator) - Université Paris-Sud
K-P Lesch (Author/Creator) - University of Würzburg
C. Lochner (Author/Creator) - Stellenbosch University
M. Luciano (Author/Creator) - University of Edinburgh
A.F. Marquand (Author/Creator) - University College London
N.G. Martin (Author/Creator) - QIMR Berghofer Medical Research Institute
I. Martínez-Zalacaín (Author/Creator) - Bellvitge University Hospital
J-L Martinot (Author/Creator) - Université Paris-Sud
D. Mataix-Cols (Author/Creator) - Karolinska Institutet
K. Mather (Author/Creator) - UNSW Sydney
C. McDonald (Author/Creator) - Ollscoil na Gaillimhe – University of Galway
K.L. McMahon (Author/Creator) - The University of Queensland
S.E. Medland (Author/Creator)
J.M. Menchón (Author/Creator) - Universitat de Barcelona
D.W. Morris (Author/Creator) - Ollscoil na Gaillimhe – University of Galway
O. Mothersill (Author/Creator) - Ollscoil na Gaillimhe – University of Galway
S.M. Maniega (Author/Creator) - University of Edinburgh
B. Mwangi (Author/Creator) - The University of Texas Health Science Center at Houston
T. Nakamae (Author/Creator) - Kyoto Prefectural University of Medicine
T. Nakao (Author/Creator) - Kyushu University
J.C. Narayanaswaamy (Author/Creator) - National Institute of Mental Health and Neurosciences
F. Nees (Author/Creator) - Heidelberg University
J.E. Nordvik (Author/Creator)
A.M.H. Onnink (Author/Creator) - Radboud University Nijmegen
N. Opel (Author/Creator) - University of Münster
R. Ophoff (Author/Creator) - University of California, Los Angeles
M-L Paillère Martinot (Author/Creator)
D. Papadopoulos Orfanos (Author/Creator)
P. Pauli (Author/Creator)
T. Paus (Author/Creator) - University of Toronto
L. Poustka (Author/Creator) - Medical University of Vienna
J.YC. Reddy (Author/Creator)
M.E. Renteria (Author/Creator) - QIMR Berghofer Medical Research Institute
R. Roiz-Santiáñez (Author/Creator)
A. Roos (Author/Creator) - Stellenbosch University
N.A. Royle (Author/Creator) - University of Edinburgh
P. Sachdev (Author/Creator) - UNSW Sydney
P. Sánchez-Juan (Author/Creator)
L. Schmaal (Author/Creator) - Vrije Universiteit Amsterdam
G. Schumann (Author/Creator) - Medical Research Council
E. Shumskaya (Author/Creator) - Radboud University Nijmegen
M.N. Smolka (Author/Creator) - Technische Universität Dresden
J.C. Soares (Author/Creator) - The University of Texas Health Science Center at Houston
C. Soriano-Mas (Author/Creator) - Universitat Autònoma de Barcelona
D.J. Stein (Author/Creator) - University of Cape Town
L.T. Strike (Author/Creator) - The University of Queensland
R. Toro (Author/Creator) - Institut Pasteur
J.A. Turner (Author/Creator)
N. Tzourio-Mazoyer (Author/Creator) - Université de Bordeaux
A. Uhlmann (Author/Creator) - University of Cape Town
M.V. Hernández (Author/Creator)
O.A. van den Heuvel (Author/Creator) - Vrije Universiteit Amsterdam
D. van der Meer (Author/Creator) - University of Groningen
N.E.M . van Haren (Author/Creator) - Utrecht University
D.J. Veltman (Author/Creator) - Vrije Universiteit Amsterdam
G. Venkatasubramanian (Author/Creator) - National Institute of Mental Health and Neurosciences
N.C. Vetter (Author/Creator) - Technische Universität Dresden
D. Vuletic (Author/Creator) - University of Cape Town
S. Walitza (Author/Creator) - University of Zurich
H. Walter (Author/Creator) - Charité - Universitätsmedizin Berlin
E. Walton (Author/Creator) - Technische Universität Dresden
Z. Wang (Author/Creator) - Shanghai Jiao Tong University
J. Wardlaw (Author/Creator) - University of Edinburgh
W. Wen (Author/Creator) - UNSW Sydney
L.T. Westlye (Author/Creator) - University of Oslo
R. Whelan (Author/Creator) - University College Dublin
K. Wittfeld (Author/Creator) - German Center for Neurodegenerative Diseases
T. Wolfers (Author/Creator) - Radboud University Nijmegen
M.J. Wright (Author/Creator) - The University of Queensland
J. Xu (Author/Creator) - Kunming Medical University
X. Xu (Author/Creator) - Kunming Medical University
J-Y Yun (Author/Creator) - Seoul National University
J.J. Zhao (Author/Creator) - Shaanxi Normal University
B. Franke (Author/Creator) - Radboud University Nijmegen
P.M. Thompson (Author/Creator) - University of Southern California
D.C. Glahn (Author/Creator) - Yale University
B. Mazoyer (Author/Creator) - Université de Bordeaux
S.E. Fisher (Author/Creator) - Radboud University Nijmegen
C. Francks (Author/Creator) - Radboud University Nijmegen
Publication Details: Brain Imaging and Behavior, Vol.11(5), pp.1497-1514
Publisher: Springer US
Identifiers: 991005541412807891
Copyright: © 2016 The Author(s)
Murdoch Affiliation: School of Engineering and Information Technology
Language: English
Resource Type: Journal article

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