Journal article
Hyperlactataemia induced by CVVHDF with low lactate bicarbonate-buffered solutions in patients with liver dysfunction
Nephrology Dialysis Transplantation, Vol.21(4), pp.1096-1099
2006
Abstract
Critical illness is often complicated by hyperlactataemia, acute renal failure, and multi-organ failure [1]. Sodium lactate is the most commonly used nonbicarbonate buffer in both dialysate and replacement solutions and as a result, significant quantities of lactate could be transferred to the patient resulting in hyperlactataemia during continuous veno-venous haemodiafiltration (CVVHDF) [2]. Hyperlactataemia is well described during CVVHDF when the lactate load exceeds the capacity of lactate metabolism in critically ill patients [1]. The liver accounts for approximately 50% of the total lactate clearance of the body and therefore patients with liver dysfunction have a reduced capacity to metabolize lactate [1]. As such, bicarbonate-buffered solutions instead of lactate-buffered solutions are recommended in these patients [2–4]. Significant hyperlactataemia induced by the use of low lactate bicarbonate-buffered replacement and dialysate solutions during CVVHDF in critically ill patients has not been described [5]. We report on two critically ill patients, both with circulatory failure and acute liver dysfunction, who developed significant hyperlactataemia during CVVHDF with the use of low lactate bicarbonate-buffered solutions.
Details
- Title
- Hyperlactataemia induced by CVVHDF with low lactate bicarbonate-buffered solutions in patients with liver dysfunction
- Authors/Creators
- K.M. Ho (Author/Creator)
- Publication Details
- Nephrology Dialysis Transplantation, Vol.21(4), pp.1096-1099
- Publisher
- Oxford University Press
- Identifiers
- 991005544077307891
- Copyright
- © 2005 The Author
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
63 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Citation topics
- 1 Clinical & Life Sciences
- 1.55 Urology & Nephrology - General
- 1.55.830 Acute Kidney Injury
- Web Of Science research areas
- Transplantation
- Urology & Nephrology
- ESI research areas
- Clinical Medicine