Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats

A.D. Pirie; N.W. Davies; K.D.K. Ahuja; M.J. Adams; C.M. Shing; C. Narkowicz; G.A. Jacobson; D.P. Geraghty

doi:10.1016/j.fct.2014.01.034

Back

Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats

Journal article

Peer reviewed

Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats

A.D. Pirie, N.W. Davies, K.D.K. Ahuja, M.J. Adams, C.M. Shing, C. Narkowicz, G.A. Jacobson and D.P. Geraghty

Food and Chemical Toxicology, Vol.66, pp.134-139

2014

DOI: https://doi.org/10.1016/j.fct.2014.01.034

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

Carpobrotus rossii (CR) was used by the Aboriginal population and early European settlers both as a food and therapeutic agent. Based on the presence of flavonoids in CR and results from our previous in vitro investigations, this study aimed to determine whether consumption of CR crude leaf extract: (a) affected lipoprotein profile, resting glucose, systolic blood pressure and vascular function, and (b) produced toxic effects (haematological measures, organ weight) in healthy rats. Male Hooded-Wistar rats (∼230 g) were supplemented for 4 weeks with CR extract in their drinking water (35 mg/kg body weight daily). CR extract produced a significant decrease (18%, p = 0.033) in atherogenic lipoproteins (but not high density lipoprotein). CR supplemented animals showed no signs of haematological toxicity and body and organ weight, daily fluid and food consumption and in vitro vascular responsiveness were similar for both groups. CR also increased (40%, p = 0.049) the renal concentration of 3-hydroxy-3-methylglutaric acid (HMG), consistent with HMG-containing CR flavonoids being bioavailable, and therefore possessing the potential to interfere with cholesterol synthesis pathways. CR extract appears to be safe to ingest and may reduce cardiovascular risk.

Details

Title: Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats
Authors/Creators: A.D. Pirie (Author/Creator) - University of Tasmania
N.W. Davies (Author/Creator) - Central Science Laboratory
K.D.K. Ahuja (Author/Creator) - University of Tasmania
M.J. Adams (Author/Creator) - University of Tasmania
C.M. Shing (Author/Creator) - University of Tasmania
C. Narkowicz (Author/Creator) - University of Tasmania
G.A. Jacobson (Author/Creator) - University of Tasmania
D.P. Geraghty (Author/Creator) - University of Tasmania
Publication Details: Food and Chemical Toxicology, Vol.66, pp.134-139
Publisher: Elsevier
Identifiers: 991005540051707891
Copyright: © 2014 Elsevier Ltd
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

32 Record Views

6 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.28 Antioxidant Activity
Web Of Science research areas: Food Science & Technology; Toxicology
ESI research areas: Pharmacology & Toxicology