Journal article
Hypothalamic lesions in multiple sclerosis
Journal of Neurology, Neurosurgery & Psychiatry, Vol.82(7), pp.819-822
2011
Abstract
Objectives To determine the frequency of hypothalamic lesions in patients with multiple sclerosis (MS) using conventional MRI (cMRI) protocols.
Methods Brain cMRI (1.5 Tesla) scans of 105 Caucasian patients with classical MS (50 with stable and 55 with more active disease) and 12 patients with longitudinal extensive myelopathy (LEM) were reviewed retrospectively. NMO-IgG antibody was assayed in patients with hypothalamic lesions.
Results Hypothalamic lesions were found in 13.3% of MS patients and in none of the LEM patients. A higher frequency of hypothalamic lesions was found in patients with active MS (18.2%) than in the stable group (8.0%), but this did not reach statistical significance (p=0.13). Patients with hypothalamic lesions also had more lesions in other cerebral structures. None of the LEM patients had hypothalamic lesions. No patients with hypothalamic lesions were positive for NMO-IgG.
Conclusions Hypothalamic lesions in MS are more frequent than previously reported and are not associated with NMO-IgG antibody.
Details
- Title
- Hypothalamic lesions in multiple sclerosis
- Authors/Creators
- W. Qiu (Author/Creator) - The University of Western AustraliaS. Raven (Author/Creator)J-S Wu (Author/Creator) - Centre for Neuromuscular and Neurological DisordersC. Bundell (Author/Creator)P. Hollingsworth (Author/Creator) - School of Pathology and Laboratory MedicineW.M. Carroll (Author/Creator) - Centre for Neuromuscular and Neurological DisordersF.L. Mastaglia (Author/Creator) - Centre for Neuromuscular and Neurological DisordersA.G. Kermode (Author/Creator) - Centre for Neuromuscular and Neurological Disorders
- Publication Details
- Journal of Neurology, Neurosurgery & Psychiatry, Vol.82(7), pp.819-822
- Publisher
- BMJ Publishing Group
- Identifiers
- 991005542496207891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Clinical Neurology
- Psychiatry
- Surgery
- ESI research areas
- Clinical Medicine