Journal article
IL-10 promoter polymorphisms influence disease severity and course in psoriasis
Genes & Immunity, Vol.4(6), pp.455-457
2003
Abstract
We analyzed three single-nucleotide polymorphisms (SNPs) at the interleukin-10 (IL-10) 5′ flanking region (positions −1082 A/G, −819 C/T and −592 C/A) in an association case–control study involving 248 patients with plaque type of psoriasis and 148 unrelated healthy volunteers using ARMS (amplification refractory mutation system)-PCR (Polymerase Chain Reaction) method. No difference was found in the frequencies of haplotype distribution between healthy controls and patients with psoriasis. There were no significant differences in the IL-10 haplotype distribution depending on the age of onset and family history of psoriasis. However, the results of our study demonstrate that the IL-10 haplotype has a role in determining severity and course of plaque type of psoriasis. IL-10 ACC haplotype (P<0.05) is likely to be defining lower activity of disease (PASI≤20; extent≤10%) and ATA haplotype is likely to be associated with persistent eruption (P<0.01). As ACC haplotype is suggested to be associated with high IL-10 secretion and ATA is related to low IL-10 secretion, potential differences in the IL-10 secretion levels might contribute the differences in the clinical course of psoriasis.
Details
- Title
- IL-10 promoter polymorphisms influence disease severity and course in psoriasis
- Authors/Creators
- K. Kingo (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuH. Silm (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of Tartu
- Publication Details
- Genes & Immunity, Vol.4(6), pp.455-457
- Publisher
- Springer Nature
- Identifiers
- 991005544122507891
- Copyright
- © 2019 Springer Nature Limited
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.737 Psoriasis
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Molecular Biology & Genetics