Journal article
IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis
Journal of Neuroimmunology, Vol.261(1-2), pp.87-91
2013
Abstract
Interleukin (IL)-22 secreting CD4+ T (Th22) cells and IL-22 are involved in the pathogenesis of autoimmune disease, but their role in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unclear. We measured the proportion of Th22, Th17, CD4+IL-22+IL-17A+ T cells and serum IL-22 in NMO and MS patients. The proportion of Th22 cells, Th17 cells and serum IL-22 were increased in patients with NMO and MS. Our findings suggest that increased Th22 cells may play an important role in the pathogenesis of NMO and MS.
Details
- Title
- IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis
- Authors/Creators
- W. Xu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityR. li (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Dai (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityA. Wu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityH. Wang (Author/Creator) - First Affiliated Hospital of Anhui Medical UniversityC. Cheng (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityW. Qiu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityZ. Lu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityX. Zhong (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Shu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityA.G. Kermode (Author/Creator) - Murdoch UniversityX. Hu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
- Publication Details
- Journal of Neuroimmunology, Vol.261(1-2), pp.87-91
- Publisher
- Elsevier
- Identifiers
- 991005546358507891
- Copyright
- 2013 Elsevier B.V.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.487 Regulatory T Cells
- Web Of Science research areas
- Immunology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior