Journal article
IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease
AIDS, Vol.23(9), pp.1173-1176
2009
Abstract
Among Australians treated for advanced HIV disease, a suboptimal virological response was associated with allele 2 at interleukin 1 alpha (IL1A)-889 and IL1A+4845. This is confirmed and investigated using patients from AIDS Clinical Trials Group study 384 (n = 532). Among non-African-American patients with CD4 T-cell count of ≤100 cells/μl at baseline, IL1A+4845TT was associated with poor virological outcome (P = 0.03). Differences were smaller with higher baseline CD4 T-cell counts. IL1A-889 and IL1A+4845 were not in linkage disequilibrium in African-American patients, and IL1A+4845T did not affect outcome.
Details
- Title
- IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease
- Authors/Creators
- P. Price (Author/Creator)I. James (Author/Creator)
- Publication Details
- AIDS, Vol.23(9), pp.1173-1176
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Identifiers
- 991005540815507891
- Copyright
- © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Web Of Science research areas
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