Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

S. Mowlaboccus; D. Daley; S. Pang; T. Gottlieb; J. Merlino; G.R. Nimmo; N. George; T.M. Korman; R. Streitberg; J. Robson; G. Peachey; P. Collignon; S. Bradbury; E. Colombi; J.P. Ramsay; B.A. Rogers; G.W. Coombs

doi:10.1016/j.ijantimicag.2020.106121

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Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

Journal article

Peer reviewed

Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

S. Mowlaboccus, D. Daley, S. Pang, T. Gottlieb, J. Merlino, G.R. Nimmo, N. George, T.M. Korman, R. Streitberg, J. Robson, …

International Journal of Antimicrobial Agents, Vol.56(4), Article 106121

2020

DOI: https://doi.org/10.1016/j.ijantimicag.2020.106121

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Abstract

Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.

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Title: Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia
Authors/Creators: S. Mowlaboccus (Author/Creator) - Murdoch University
D. Daley (Author/Creator) - Fiona Stanley Hospital
S. Pang (Author/Creator) - Fiona Stanley Hospital
T. Gottlieb (Author/Creator) - Concord Repatriation General Hospital
J. Merlino (Author/Creator) - Concord Repatriation General Hospital
G.R. Nimmo (Author/Creator) - Pathology Queensland Central Laboratory, Herston, QLD, Australia.
N. George (Author/Creator) - Pathology Queensland Central Laboratory, Herston, QLD, Australia.
T.M. Korman (Author/Creator) - Monash University
R. Streitberg (Author/Creator) - Monash Health
J. Robson (Author/Creator) - Sullivan Nicolaides Pathology
G. Peachey (Author/Creator) - Concord Repatriation General Hospital
P. Collignon (Author/Creator) - Canberra Hospital
S. Bradbury (Author/Creator) - Canberra Hospital
E. Colombi (Author/Creator) - Curtin University
J.P. Ramsay (Author/Creator) - Curtin University
B.A. Rogers (Author/Creator) - Monash University
G.W. Coombs (Author/Creator) - Fiona Stanley Hospital
Publication Details: International Journal of Antimicrobial Agents, Vol.56(4), Article 106121
Publisher: Elsevier
Identifiers: 991005545134207891
Copyright: © 2020 Elsevier Ltd and International Society of Antimicrobial Chemotherapy
Murdoch Affiliation: School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.146 Antimicrobial Resistance
Web Of Science research areas: Infectious Diseases; Microbiology; Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology