Identification of a ribonuclease H gene in both Mycoplasma genitalium and Mycoplasma pneumoniae by a new method for exhaustive identification of ORFs in the complete genome sequences

M.I. Bellgard; T. Gojobori

doi:10.1016/S0014-5793(99)00075-7

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Identification of a ribonuclease H gene in both Mycoplasma genitalium and Mycoplasma pneumoniae by a new method for exhaustive identification of ORFs in the complete genome sequences

Journal article

Peer reviewed

Identification of a ribonuclease H gene in both Mycoplasma genitalium and Mycoplasma pneumoniae by a new method for exhaustive identification of ORFs in the complete genome sequences

M.I. Bellgard and T. Gojobori

FEBS Letters, Vol.445(1), pp.6-8

1999

DOI: https://doi.org/10.1016/S0014-5793(99)00075-7

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Abstract

Exhaustive identification of open reading frames in complete genome sequences is a difficult task. It is possible that important genes are missed. In our efforts to reanalyze the intergenic regions of Mycoplasma genitalium and Mycoplasma pneumoniae, we have newly identified a number of new open reading frames (ORFs) in both M. genitalium and M. pneumoniae. The most significant identification was that of a ribonuclease H enzyme in both species which until now has not been identified or assumed absent and interpreted as such. In this paper we discuss the biological importance of RNase H and its evolutionary implication. We also stress the usefulness of our method for identifying new ORFs by reanalyzing intergenic regions of existing ORFs in complete genome sequences.

Details

Title: Identification of a ribonuclease H gene in both Mycoplasma genitalium and Mycoplasma pneumoniae by a new method for exhaustive identification of ORFs in the complete genome sequences
Authors/Creators: M.I. Bellgard (Author/Creator)
T. Gojobori (Author/Creator)
Publication Details: FEBS Letters, Vol.445(1), pp.6-8
Publisher: Elsevier
Identifiers: 991005545282907891
Copyright: 1999 Federation of European Biochemical Societies
Murdoch Affiliation: School of Information Technology
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.762 Antiviral Nucleosides
Web Of Science research areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology
ESI research areas: Biology & Biochemistry