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CC BY-NC-ND V4.0, Open Access
Journal article
Identification of immunogenic and cross-reactive chikungunya virus epitopes for CD4 + T cells in chronic chikungunya disease
Nature communications, Vol.16(1), 5756
2025
PMID: 40592820
Abstract
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes acute febrile illness that can progress into chronic arthritis-like disease (CHIKVD) in humans. CD4
T cells have important functions in CHIKV infection, yet the CHIKV target proteins for these CD4 + T cells are poorly characterized. Here, by stimulating PBMCs collected from individuals with chronic CHIKVD with peptides spanning the entire CHIKV proteome, we provide a comprehensive landscape of CHIKV CD4
T cell epitopes. We identify three immunodominant regions and associated core motifs in CHIKV E1, nsP1 and CP proteins. In addition, by in silico assessment of the sequence conservation of CHIKV proteome with closely related alphaviruses, we define CHIKV epitopes conserved across arthritogenic and encephalitic viruses. Overall, our work describes CD4
T cell targets of CHIKV in humans, thereby assisting in studying the functions of CD4
T cells in CHIKV pathogenesis and vaccine design.
Details
- Title
- Identification of immunogenic and cross-reactive chikungunya virus epitopes for CD4 + T cells in chronic chikungunya disease
- Authors/Creators
- Rimjhim Agarwal - La Jolla Institute for ImmunologyCalvin Ha - La Jolla Institute for ImmunologyFernanda H Côrtes - La Jolla Institute for ImmunologyYeji Lee - La Jolla Institute for ImmunologyAmparo Martínez-Pérez - La Jolla Institute for ImmunologyRosa Isela Gálvez - La Jolla Institute for ImmunologyIzabella N Castillo - University of North Carolina at Chapel HillElizabeth J Phillips - Vanderbilt University School of Medicine, Nashville, Tennessee, USASimon A Mallal - Vanderbilt University School of Medicine, Nashville, Tennessee, USAAngel Balmaseda - Sustainable Sciences InstituteEva Harris - University of California, BerkeleyClaudia M Romero-Vivas - Universidad del NorteLakshmanane Premkumar - University of North Carolina at Chapel HillAndrew K Falconar - Universidad del NorteAlba Grifoni - La Jolla Institute for ImmunologyAlessandro Sette - La Jolla Institute for ImmunologyDaniela Weiskopf - La Jolla Institute for Immunology
- Publication Details
- Nature communications, Vol.16(1), 5756
- Publisher
- Springer Nature
- Grant note
- 75N93019C00065 / NIAID NIH HHS 75N93024C00056 / NIAID NIH HHS
- Identifiers
- 991005792773507891
- Copyright
- © The Author(s) 2025
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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