Identification of two new C4 alleles by DNA sequencing and evidence for a historical recombination of serologically defined C4A and C4B alleles

J. Hui; A. Oka; M. Tomizawa; G.K. Tay; J.K. Kulski; W.J. Penhale; S.P.A. Iaschi; S. Makino; G. Tamiya; H. Inoko

doi:10.1111/j.1399-0039.2004.0175.x

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Identification of two new C4 alleles by DNA sequencing and evidence for a historical recombination of serologically defined C4A and C4B alleles

Journal article

Peer reviewed

Identification of two new C4 alleles by DNA sequencing and evidence for a historical recombination of serologically defined C4A and C4B alleles

J. Hui, A. Oka, M. Tomizawa, G.K. Tay, J.K. Kulski, W.J. Penhale, S.P.A. Iaschi, S. Makino, G. Tamiya and H. Inoko

Tissue Antigens, Vol.63(3), pp.263-269

2004

DOI: https://doi.org/10.1111/j.1399-0039.2004.0175.x

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Abstract

Nucleotide polymorphisms of the C4 genes were investigated by direct sequencing of seven different homozygous typing cells from the 10IHW panels. Two novel sequences were identified within the C4d region of the C4 genes. Our sequencing analyses extend previous findings suggesting that a recombination hot spot is likely to have occurred between codon positions 1157 and 1186 within the C4d region. The classification of electrophoretically defined C4A and C4B alleles can be further subtyped by sequencing. Because the central major histocompatibility complex region that carries various copies of the C4 gene has been associated with a range of disorders; further analysis at the sequence level within the C4 locus may provide informative genetic markers for the investigation of disease-associated polymorphisms.

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Title: Identification of two new C4 alleles by DNA sequencing and evidence for a historical recombination of serologically defined C4A and C4B alleles
Authors/Creators: J. Hui (Author/Creator)
A. Oka (Author/Creator)
M. Tomizawa (Author/Creator)
G.K. Tay (Author/Creator)
J.K. Kulski (Author/Creator)
W.J. Penhale (Author/Creator)
S.P.A. Iaschi (Author/Creator)
S. Makino (Author/Creator)
G. Tamiya (Author/Creator)
H. Inoko (Author/Creator)
Publication Details: Tissue Antigens, Vol.63(3), pp.263-269
Publisher: Blackwell Publishing
Identifiers: 991005540712607891
Murdoch Affiliation: Centre for Comparative Genomics; School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.286 Immunology & Hematology; 1.286.845 Complement System
Web Of Science research areas: Cell Biology; Immunology; Pathology
ESI research areas: Molecular Biology & Genetics