Identification of two new alleles in a single Korean individual, HLA-B*1568 and HLA-DRB1*1208

M.H. Sheldon; M. Bunce; P.P.J. Dunn; S. Day; G.D. Lee; Y-J. Park; B.K. Bang; B.K. Kim; E-J. Oh

doi:10.1034/j.1399-0039.2002.590513.x

Back

Identification of two new alleles in a single Korean individual, HLA-B*1568 and HLA-DRB1*1208

Journal article

Peer reviewed

Identification of two new alleles in a single Korean individual, HLA-B1568 and HLA-DRB11208

M.H. Sheldon, M. Bunce, P.P.J. Dunn, S. Day, G.D. Lee, Y-J. Park, B.K. Bang, B.K. Kim and E-J. Oh

Tissue Antigens, Vol.59(5), pp.430-432

2002

DOI: https://doi.org/10.1034/j.1399-0039.2002.590513.x

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

We have identified a new HLA-B*15 allele and a new HLA-DRB1*12 allele, named B*1568 and DRB1*1208, respectively. The alleles were identified using a combination of sequence specific primers, reverse line sequence specific oligonucleotide probing and sequence-based typing. Both alleles were identified in a single individual of Korean origin. HLAB*1568 appears to be an HLA-B*4801/B*1507 hybrid combining the exon 2 sequence of B*4801 and the exon 3 and 4 sequences of B*1507. Exon 2 of DRB1*1208 was most similar to DRB1*1201 or 1206, with a single mismatch at nucleotide position 165 (A to C). At the protein level, this substitution results in a phenylalanine substitution at position 26 that creates an identical amino acid sequence to DRB3*0202 between amino acid positions 17 and 36.

Details

Title: Identification of two new alleles in a single Korean individual, HLA-B*1568 and HLA-DRB1*1208
Authors/Creators: M.H. Sheldon (Author/Creator)
M. Bunce (Author/Creator)
P.P.J. Dunn (Author/Creator)
S. Day (Author/Creator)
G.D. Lee (Author/Creator)
Y-J. Park (Author/Creator)
B.K. Bang (Author/Creator)
B.K. Kim (Author/Creator)
E-J. Oh (Author/Creator)
Publication Details: Tissue Antigens, Vol.59(5), pp.430-432
Publisher: Blackwell Publishing
Identifiers: 991005543657207891
Copyright: © 2002 Blackwell Munksgaard
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

28 Record Views

1 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Cell Biology; Immunology; Pathology
ESI research areas: Molecular Biology & Genetics