Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge

S.P. Chen; M.C. Lee; Y. Sun; I.C. Cheng; P.C. Yang; Y-C Lin; M.H. Jong; I.D. Robertson; J.R. Edwards; T.M. Ellis

doi:10.1016/j.vaccine.2007.03.019

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Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge

Journal article

Peer reviewed

Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge

S.P. Chen, M.C. Lee, Y. Sun, I.C. Cheng, P.C. Yang, Y-C Lin, M.H. Jong, I.D. Robertson, J.R. Edwards and T.M. Ellis

Vaccine, Vol.25(22), pp.4464-4469

05/2007

DOI: https://doi.org/10.1016/j.vaccine.2007.03.019

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Abstract

The immune response to structural and non-structural proteins (NSPs) was studied on sequential serum samples in swine from O/Taiwan/97 FMDV challenge studies, outbreaks and after vaccination. The results showed that pigs vaccinated with a commercial vaccine prior to or after infection maintained high neutralizing antibody titers with gradual decline from peak titers over the duration of this study. However, neutralizing antibody titers in non-vaccinated pigs only reached moderate levels 2-4 weeks post infection and remained low thereafter. For the 3B and 3ABC NSP antibody ELISA responses, there were gradually decreasing levels of NSP antibody over time. In multiple vaccinations, all pigs showed significant increases in neutralizing antibodies after booster vaccination. For the 3B NSP antibody ELISA after vaccination, the mean S/P ratios for pigs vaccinated with all three FMD vaccines were all below the 0.23 cut-off value set by the manufacture, but some sera from individual vaccinated pigs gave results above this cut-off after primary or secondary vaccination. However, with the 3ABC NSP antibody ELISA, all sera from vaccinated pigs had negative results for NSP antibody for all time points.

Details

Title: Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge
Authors/Creators: S.P. Chen (Author/Creator) - Animal Technology Institute Taiwan
M.C. Lee (Author/Creator) - Animal Technology Institute Taiwan
Y. Sun (Author/Creator) - Animal Technology Institute Taiwan
I.C. Cheng (Author/Creator) - Animal Technology Institute Taiwan
P.C. Yang (Author/Creator) - Animal Technology Institute Taiwan
Y-C Lin (Author/Creator)
M.H. Jong (Author/Creator) - Council of Agriculture
I.D. Robertson (Author/Creator) - Murdoch University
J.R. Edwards (Author/Creator) - Murdoch University
T.M. Ellis (Author/Creator) - Murdoch University
Publication Details: Vaccine, Vol.25(22), pp.4464-4469
Publisher: Elsevier BV
Identifiers: 991005543593007891
Copyright: © 2007 Elsevier Ltd. All rights reserved.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.901 Enterovirus Research
Web Of Science research areas: Immunology; Medicine, Research & Experimental
ESI research areas: Immunology