Journal article
Immunohistochemical expression of the PRO2268 protein in psoriasis vulgaris skin
Human Immunology, Vol.72(6), pp.522-524
2011
Abstract
The PRO2268 gene encodes for the PRO2268 molecule and maps to a chromosomal region (12q14), which clusters genes with a key role in immune signaling. Although the PRO2268 protein is as yet of unknown function, we should not exclude the possibility that the PRO2268 gene, because of its location, might have a distinct role in autoimmunity and inflammation. The aim of the present study was to investigate the expression pattern of the PRO2268 protein in psoriasis skin. Formalin-fixed paraffin-embedded sections from normal and psoriasis skin tissue were studied immunohistochemically using custom-ordered antibodies (anti-PRO2268#1 and anti-PRO2268#2) against the PRO2268. The present study revealed an expression of the anti-PRO2268#2 in the inflammatory infiltrate, and suggesting a possible role for the PRO2268 molecule in pathophysiology of psoriasis, which needs further investigation.
Details
- Title
- Immunohistochemical expression of the PRO2268 protein in psoriasis vulgaris skin
- Authors/Creators
- K. Douroudis (Author/Creator) - University of TartuM. Sirotkina (Author/Creator) - Tartu University HospitalK. Kingo (Author/Creator) - University of TartuR. Mössner (Author/Creator) - University of GöttingenS. Kõks (Author/Creator) - University of Tartu
- Publication Details
- Human Immunology, Vol.72(6), pp.522-524
- Publisher
- Elsevier BV
- Identifiers
- 991005542209007891
- Copyright
- © 2011 American Society for Histocompatibility and Immunogenetics.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.737 Psoriasis
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology